发明公开
EP1330470A1 GLUTATHIONE CONJUGATES WITH DISTAMYCIN DERIVATIVES HAVING ANTITUMOR ACTIVITY
审中-公开
与偏端霉素衍生物，谷胱甘肽结合物和它们作为抗肿瘤剂的用途
- 专利标题： GLUTATHIONE CONJUGATES WITH DISTAMYCIN DERIVATIVES HAVING ANTITUMOR ACTIVITY
- 专利标题（中）： 与偏端霉素衍生物，谷胱甘肽结合物和它们作为抗肿瘤剂的用途
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申请号： EP01972032.5申请日： 2001-09-07
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公开(公告)号： EP1330470A1公开(公告)日： 2003-07-30
- 发明人: BERIA, Italo , COZZI, Paolo , GERONI, Maria, Cristina
- 申请人： Pharmacia Italia S.p.A.
- 申请人地址： Via Robert Koch 1.2 20152 Milano IT
- 专利权人： Pharmacia Italia S.p.A.
- 当前专利权人： Pharmacia Italia S.p.A.
- 当前专利权人地址： Via Robert Koch 1.2 20152 Milano IT
- 代理机构： Longoni, Alessandra
- 优先权： ITMI000201 20000915
- 国际公布： WO02022655 20020321
- 主分类号： C07K5/02
- IPC分类号： C07K5/02 ; A61K38/06 ; C07K5/037
摘要：
The present invention refers to distamycin and derivatives thereof, such as bromo-or chloro-acryloyl derivatives of distamycin, which are conjugated with glutathione, to a process for their preparation and to pharmaceutical compositions thereof. The compounds of the invention are endowed with a remarkable antitumor activity and are thus useful in therapy in the treatment of cancer.
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