发明公开
EP1331937A2 DIBENZOXAZEPINE ALPHA V INTEGRIN RECEPTOR ANTAGONIST
有权
DIBENZOXAZEPIN-ALPHA-V整合素REZEPTORANTAGONIST
- 专利标题： DIBENZOXAZEPINE ALPHA V INTEGRIN RECEPTOR ANTAGONIST
- 专利标题（中）： DIBENZOXAZEPIN-ALPHA-V整合素REZEPTORANTAGONIST
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申请号： EP01987196.1申请日： 2001-10-19
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公开(公告)号： EP1331937A2公开(公告)日： 2003-08-06
- 发明人: PATANE, Michael, A.
- 申请人： Merck & Co., Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway,New Jersey 07065-0907 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway,New Jersey 07065-0907 US
- 代理机构： Hiscock, Ian James
- 优先权： US242829P 20001024
- 国际公布： WO02040505 20020523
- 主分类号： A61K31/553
- IPC分类号： A61K31/553 ; A61P19/10 ; C07D267/16
摘要：
The present invention relates to a novel dibenzoxazepine derivative, its synthesis, and its use as an αξ integrin receptor antagonist. More particularly, the compound of the present invention is an antagonist of the integrin receptors αξβ3 and αξβ5 and therefor useful for inhibiting bone resorption, treating and/or preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, artherosclerosis, inflammatory arthritis, cancer and metastatic tumor growth.
公开/授权文献
- EP1331937B1 DIBENZOXAZEPINE ALPHA V INTEGRIN RECEPTOR ANTAGONIST 公开/授权日：2006-03-15
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