发明公开
EP1341771A2 BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS
审中-公开
苯并咪唑衍生物和它们作为TIE-2和/或VEGFR-2抑制剂的用途
- 专利标题： BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS
- 专利标题（中）： 苯并咪唑衍生物和它们作为TIE-2和/或VEGFR-2抑制剂的用途
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申请号： EP01991963.8申请日： 2001-11-28
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公开(公告)号： EP1341771A2公开(公告)日： 2003-09-10
- 发明人: CHEUNG, Mui,GlaxoSmithKline , HARRIS, Philip Anthony,GlaxoSmithKline , HASEGAWA, Masaichi,GlaxoSmithKline , IDA, Satoru,GlaxoSmithKline , KANO, Kazuya,GlaxoSmithKline , NISHIGAKI, Naohiko,GlaxoSmithKline , SATO, Hideyuki,GlaxoSmithKline , VEAL, James Martin,GlaxoSmithKline , WASHIO, Yoshiaki,GlaxoSmithKline , WEST, Rob I.,GlaxoSmithKline
- 申请人： GLAXO GROUP LIMITED
- 申请人地址： Glaxo Wellcome House,Berkeley Avenue Greenford,Middlesex UB6 0NN GB
- 专利权人： GLAXO GROUP LIMITED
- 当前专利权人： GLAXO GROUP LIMITED
- 当前专利权人地址： Glaxo Wellcome House,Berkeley Avenue Greenford,Middlesex UB6 0NN GB
- 代理机构： Bor, Fiona Rachel
- 优先权： US253868P 20001129; US310939P 20010808
- 国际公布： WO02044156 20020606
- 主分类号： C07D235/32
- IPC分类号： C07D235/32 ; C07D235/30 ; C07D405/12 ; C07D401/12 ; C07D277/82 ; A61K31/4184 ; A61K31/4188 ; A61K31/428 ; A61K31/423 ; A61P35/00 ; C07D471/04 ; C07D471/14 ; C07D403/12 ; C07D409/12 ; C07D487/04 ; C07D263/58 ; C07D413/12 ; C07D417/12 ; C07D413/14 ; C07D417/14 ; C07D405/14
摘要：
Benzimidazole derivatives of Formula (I), which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
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