Patent search ipc:"A61K31/4184" Page 1

1.

发明授权
COMPOSITIONS AND METHODS FOR THE TREATMENT OF ADENOMYOSIS AND RECTOVAGINAL ENDOMETRIOSIS 有权

公开(公告)号：EP3873465B1

公开(公告)日：2025-01-15

申请号：EP19798018.8

申请日：2019-10-29

Inventor： GOTTELAND, Jean-Pierre , LOUMAYE, Ernest

IPC: A61K31/4184 , A61K31/4439 , A61K31/513 , A61K31/519 , A61K45/06 , A61P15/00 , A61P15/02

2.

发明授权
UBE2N INHIBITORS FOR USE IN THE TREATMENT OF ACUTE MYELOMONOCYTIC LEUKEMIA (AML-M4) AND/OR ACUTE MONOCYTIC LEUKEMIA (AML-M5). 有权

公开(公告)号：EP3983533B1

公开(公告)日：2025-01-08

申请号：EP20822638.1

申请日：2020-06-15

Inventor： STARCZYNOWSKI, Daniel , BARREYRO, Laura , SEIBEL, William

IPC: A61K31/4184 , A61K31/454 , A61K31/635 , C12N9/00 , C12Q1/6886 , G01N33/50 , A61K45/06 , A61P35/02 , A61K31/345

3.

发明公开
FUSED QUINONE OXIME IMIDAZOLE, ONIUM DERIVATIVE THEREOF, PREPARATION THEREFOR AND USE THEREOF 审中-公开

公开(公告)号：EP4484412A1

公开(公告)日：2025-01-01

申请号：EP22930534.7

申请日：2022-08-17

Applicant: Shanghai Jiao Tong University

Inventor： ZHANG, Wanbin , YAN, Deyue , YUAN, Jing , ZHANG, Zhenfeng

IPC: C07D235/02 , C07D409/06 , C07D405/06 , C07D403/06 , C07D405/04 , C07D409/04 , C07D405/12 , A61K31/4184 , A61K31/497 , A61P35/00 , A61P31/04 , A61P31/12

Abstract: The present invention discloses a fused quinonoxime imidazole, an onium derivative thereof, preparation and use thereof; the fused quinonoxime imidazole and an onium derivative thereof having structures represented by the following Formulas (I), (II), (III) and (IV).

The present invention has a novel structure, where the substituted quinone imidazole and the onium derivative thereof are fused with an aromatic carbon ring or a heterocyclic ring, and are characterized by oximation substitution. The derivative shows good inhibition activity against tumor cell growth, exhibits excellent selectivity, and has a good antitumor application prospect through in vitro and in vivo tests. Moreover, the antiviral and antibacterial effects thereof are also very good.

4.

发明公开
PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OR PREVENTION OF CANCER 审中-公开

公开(公告)号：EP4483866A1

公开(公告)日：2025-01-01

申请号：EP23182027.5

申请日：2023-06-28

Applicant: Makrolife Biotech GmbH

Inventor： AHMAD, Fähzan

IPC: A61K31/045 , A61K31/05 , A61K31/12 , A61K31/352 , A61K31/404 , A61K31/4412 , A61K45/06 , A61P35/00 , A61K31/09 , A61K31/167 , A61K31/194 , A61K31/215 , A61K31/216 , A61K31/235 , A61K31/351 , A61K31/4025 , A61K31/4045 , A61K31/405 , A61K31/415 , A61K31/4152 , A61K31/4184

Abstract: The invention relates to pharmaceutical compositions comprising at least one active compound having the property of polarization or differentiation of monocytes, and repolarization of macrophages into a phenotype with anti-tumor properties, the active compound being selected from the group consisting of apigenin derivative, indol-3-carbinol derivative, lupeol derivative, piperlongumin derivative, quercetin derivative, curcumin derivative and/or resveratrol derivative, or a mixture thereof, and a suitable pharmaceutical carrier. The pharmaceutical compositions are suitable for the treatment or prevention of different types of cancer. The invention furthermore relates to an in-vitro method for polarization or differentiation of monocytes or peripheral blood mononuclear cells (PBMCs) into macrophages with a M1-like phenotype with anti-tumor properties. The invention further relates to a method of preparation of repolarized macrophages with M1-like phenotype with anti-tumor properties.

5.

发明公开
DRUG COMBINATIONS AND METHODS OF TREATING OVARIAN CANCER 审中-公开

公开(公告)号：EP4479047A1

公开(公告)日：2024-12-25

申请号：EP23757124.5

申请日：2023-02-17

Applicant: Pattern Computer, Inc.

Inventor： SINGH, Nidhi , WOLF-YADLIN, Alejandro

IPC: A61K31/4184 , A61K31/395 , A61K31/505 , A61K31/4162 , A61K31/33

6.

发明公开
TREATMENT OF COLON CANCER WITH A COMBINATION OF THE HDAC INHIBITOR HBI-800 AND A PD-L1 INHIBITOR 审中-公开

公开(公告)号：EP4450085A3

公开(公告)日：2024-12-25

申请号：EP24185599.8

申请日：2017-05-11

Applicant: Huyabio International, LLC

Inventor： BISSONNETTE, Reid, P. , ROLLAND, Alain , BISSONNETTE, Reid, P.

IPC: A61K31/167 , A61K31/18 , A61K31/13 , A61K39/21 , A61K31/136 , C07K14/16 , C12Q1/68 , C12Q1/70 , A61P35/00 , A61K31/395 , A61K31/4184 , A61K31/506 , A61K31/343 , A61K31/4045 , A61K31/4406 , A61K38/15 , A61K45/06 , C07K16/28 , A61K39/395

Abstract: Provided herein are combinations that include an HDACi and a PD-1 inhibitor that are useful for treating cancer, including reducing and/or preventing cancer metastasis. The combination is also useful for treating cancer that has been previously treated with a PD-L1 inhibitor.