发明公开
- 专利标题： LFA-1 ANTAGONIST COMPOUNDS
- 专利标题（中）： LFA-1受体拮抗剂
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申请号： EP01997016.9申请日： 2001-11-26
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公开(公告)号： EP1347968A1公开(公告)日： 2003-10-01
- 发明人: BURDICK, Daniel, J. , GADEK, Thomas, R. , MARSTERS James, C., Jr. , OARE, David , REYNOLDS, Mark, E. , STANLEY, Mark, S.
- 申请人： GENENTECH, INC.
- 申请人地址： 1 DNA Way South San Francisco California 94080 US
- 专利权人： GENENTECH, INC.
- 当前专利权人： GENENTECH, INC.
- 当前专利权人地址： 1 DNA Way South San Francisco California 94080 US
- 代理机构： Barz, Peter
- 优先权： US253682P 20001128
- 国际公布： WO02059114 20020801
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; C07D417/12 ; C07D207/16 ; A61P37/06 ; A61K31/34 ; A61K31/425 ; A61K31/40
摘要：
The invention relates to novel compounds having formula (I), wherein Cy, X, Y, L and R1-6 are as defined herein. The compounds bind CD11/CD18 adhesion receptors such as Lymphocyte Function-associated Antigen-1 (LFA-1) and are therefore useful for treating disorders mediated by LFA-1 such as inflammation
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