公开(公告)号：EP1347968A1

公开(公告)日：2003-10-01

申请号：EP01997016.9

申请日：2001-11-26

申请人： GENENTECH, INC.

发明人： BURDICK, Daniel, J. ,  GADEK, Thomas, R. ,  MARSTERS James, C., Jr. ,  OARE, David ,  REYNOLDS, Mark, E. ,  STANLEY, Mark, S.

IPC分类号： C07D405/12 ,  C07D417/12 ,  C07D207/16 ,  A61P37/06 ,  A61K31/34 ,  A61K31/425 ,  A61K31/40

CPC分类号： C07D405/12 ,  A61K31/198 ,  A61K31/40 ,  A61K31/44 ,  C07D207/16 ,  C07D277/06 ,  C07D307/54 ,  C07D417/12

摘要： The invention relates to novel compounds having formula (I), wherein Cy, X, Y, L and R1-6 are as defined herein. The compounds bind CD11/CD18 adhesion receptors such as Lymphocyte Function-associated Antigen-1 (LFA-1) and are therefore useful for treating disorders mediated by LFA-1 such as inflammation

公开(公告)号：EP1276702A2

公开(公告)日：2003-01-22

申请号：EP01922986.3

申请日：2001-03-30

申请人： GENENTECH, INC.

发明人： LOWE, David, G. ,  MARSTERS James, C., Jr. ,  ROBBIE, Edward, P. ,  SMITH, Victoria

IPC分类号： C03C17/34 ,  C12Q1/68

CPC分类号： G01N33/54353 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00385 ,  B01J2219/00427 ,  B01J2219/00529 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00677 ,  B01J2219/00722 ,  B82Y30/00 ,  C03C17/3405 ,  C12Q1/6837 ,  C40B40/06 ,  C40B60/14 ,  G01N33/6893 ,  G01N2800/24

摘要： Compositions and methods for improving detection sensitivity in nucleic acid microarray analysis are disclosed, including methods of purifying nucleic acids, methods of synthesizing fluorescent DNA probes, methods of hybridization, and methods of activating a substrate for target molecule attachment are disclosed.