The invention relates to a material for detoxification of blood (4), containing foreign toxic substances (X), comprising at least: one blood-permeable and blood-compatible matrix (2), in particular, in the form of a membrane (1) and a molecular sieve, incorporated in the matrix (2), or produced as a matrix and loaded with a chromatographic solution (Y) at a pH value of 7.5 ± 0.5, in particular in the form of a cationic solution, whereby the chromatographed molecular sieve (3) performs the detoxification of the blood (4). The above material is characterised in that the chromatographed molecular sieve (3) additionally contains water of crystallisation such that the molecular sieve is partially dehydrated in relation to the full molecular amount (m) of water of crystallisation and said molecular sieve with the reduced molecular amount (m') of water of crystallisation is loaded with the chromatographic solution (Y). The invention further relates to an advantageous method for production of the above material.