发明公开
EP1349823A1 PROCESS FOR BASE-PROMOTED CONDENSATION REACTIONS AND BASE REAGENT THEREFOR
无效
程序对于底数辅助的缩合反应确保两BASENREAGENS
- 专利标题： PROCESS FOR BASE-PROMOTED CONDENSATION REACTIONS AND BASE REAGENT THEREFOR
- 专利标题（中）： 程序对于底数辅助的缩合反应确保两BASENREAGENS
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申请号： EP02700985.1申请日： 2002-01-08
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公开(公告)号： EP1349823A1公开(公告)日： 2003-10-08
- 发明人: FISCH, Michael, H. , KRAINER, Edward , BACALOGLU, Radu
- 申请人： Crompton Corporation
- 申请人地址： 199 Benson Road Middlebury, Connecticut 06749 US
- 专利权人： Crompton Corporation
- 当前专利权人： Crompton Corporation
- 当前专利权人地址： 199 Benson Road Middlebury, Connecticut 06749 US
- 代理机构： Spott, Gottfried, Dr.
- 优先权： US261614P 20010112; US769429 20010126
- 国际公布： WO02055466 20020718
- 主分类号： C07C45/45
- IPC分类号： C07C45/45 ; C07C49/782 ; C07C29/70 ; C07C31/30
摘要：
A method for the preparation of 1,3-diketones is disclosed wherein the method comprises the steps of: (A) mixing an alkali metal base with a hindered alcohol in an aromatic hydrocarbon solvent; (B) boiling the mixture and azeotropically distilling water formed by the reaction between the base and the alcohol, whereby a solution of a hindered alkali metal alkoxide is formed in situ in the solvent; (C) mixing an ester with the solution of the hindered alkali metal alkoxide in the aromatic hydrocarbon solvent; and then (D) adding a ketone to the mixture.
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