发明授权
EP1349846B1 ARYLIERTE FURAN- UND THIOPHENCARBONSAUREAMIDE MIT KALIUM KANAL BLOCKIERENDER WIRKUNG
有权
芳基化呋喃和THIOPHENCARBONSAUREAMIDE钾通道阻断作用
- 专利标题: ARYLIERTE FURAN- UND THIOPHENCARBONSAUREAMIDE MIT KALIUM KANAL BLOCKIERENDER WIRKUNG
- 专利标题(英): Arylated furane and thiophene carboxylic acid amides with potassium channel blocking effect
- 专利标题(中): 芳基化呋喃和THIOPHENCARBONSAUREAMIDE钾通道阻断作用
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申请号: EP01985832.3申请日: 2001-11-29
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公开(公告)号: EP1349846B1公开(公告)日: 2005-02-09
- 发明人: PEUKERT, Stefan , BRENDEL, Joachim , HEMMERLE, Horst , KLEEMANN, Heinz-Werner
- 申请人: Aventis Pharma Deutschland GmbH
- 申请人地址: Brüningstrasse 50 65929 Frankfurt am Main DE
- 专利权人: Aventis Pharma Deutschland GmbH
- 当前专利权人: Aventis Pharma Deutschland GmbH
- 当前专利权人地址: Brüningstrasse 50 65929 Frankfurt am Main DE
- 优先权: DE10061876 20001212
- 国际公布: WO2002048131 20020620
- 主分类号: C07D307/68
- IPC分类号: C07D307/68 ; C07D333/38 ; A61K31/38 ; A61K31/34 ; A61P9/06
摘要:
The invention relates to arylated furane and thiophene carboxylic acid amides, a method for the production thereof, the use thereof as medicaments, in addition to pharmaceutical preparations containing the compounds of formula (Ia) and (Ib) wherein X, R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(30) and R(31) have the same meaning as cited in the claims. According to the invention, the compounds are particularly suitable as novel anti-arrhythmic active ingredients, particularly for the treatment and prophylaxis of atrial arrhythmia for example, atrial fibrillation, AF, or atrial flutter.
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