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1.发明授权ORTHO-SUBSTITUIERTE STICKSTOFFHALTIGE BISARYLVERBINDUNGEN ZUR VERWENDUNG ALS KALIUM-KANAL-INHIBITOREN 有权邻位取代的含氮BISARYLVERBINDUNGEN用作钾通道阻断剂
公开(公告)号：EP1341764B1
公开(公告)日：2005-06-15
申请号：EP01999558.8
申请日：2001-11-24
IPC分类号： C07D213/81 , C07D213/82 , C07D241/24 , C07D213/56 , C07D401/12 , C07D413/12 , A61K31/497 , A61P9/06
CPC分类号： C07D213/81 , C07D213/56 , C07D213/82 , C07D241/24 , C07D401/12 , C07D413/12
摘要： Compounds of formula (I) wherein A1 - A8, R(1), R(2), R(3), R(4), R(30) and R(31) have the meanings cited in the claims. Said compounds are particularly suitable for use as novel antiarrythmic substances, especially in the treatment and prophylaxis of atrial arrhythmia, for example, atrial fibrillation (AF) or atrial flutter.
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2.发明公开ANTHRANILSÄUREAMIDE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS ANTIARRHYTHMIKA SOWIE PHARMAZEUTISCHE ZUBEREITUNGEN DAVON 有权邻氨基，PROCESS FOR THEIR，它们的使用抗心律不齐药物及其制备物
公开(公告)号：EP1385820A1
公开(公告)日：2004-02-04
申请号：EP02742898.6
申请日：2002-04-13
发明人： BRENDEL, Joachim , PIRARD, Bernard , PEUKERT, Stefan , KLEEMANN, Heinz-Werner , HEMMERLE, Horst
IPC分类号： C07C311/21 , C07C311/29 , C07D213/56 , C07C311/08 , C07D233/64 , C07D235/16 , C07D307/54 , C07D277/30 , C07D215/14 , C07D231/12 , A61K31/18
CPC分类号： C07D207/335 , C07C311/08 , C07C311/21 , C07C311/29 , C07C311/44 , C07C2601/02 , C07C2601/14 , C07D213/40 , C07D213/64 , C07D215/12 , C07D231/12 , C07D231/16 , C07D233/56 , C07D233/64 , C07D235/14 , C07D249/08 , C07D277/28 , C07D307/14 , C07D307/52 , C07D405/12
摘要： The invention relates to anthranilic acid amides, to a method for the production thereof, to their use as a medicament, and to pharmaceutical preparations containing these anthranilic acid amides. The anthranilic acid amides consist of compounds of formula (I) in which R(1) to (R7) have the meanings as cited in the claims, act upon the Kv1.5 potassium channel, and inhibit a potassium stream described as an 'ultra-rapidly activating delayed rectifier' in the human cardiac atrium. The compounds are therefore especially suited as novel antiarrhythmic active substances, particularly for treating and preventing atrial arrhythmias, e.g. atrial fibrillation AF or atrial flutter.
摘要翻译： 本发明涉及式I的邻氨基苯甲酰胺，其中R（1）〜R（7）的含义为在中，其制备方法，它们作为药物的用途以及含有它们的药物制剂。 这些化合物作用于对Kv1.5钾通道和抑制钾电流的所有其通过被称为在人类心脏的心房超快速激活延迟整流。 的化合物是适于用作用于治疗THEREFORE新颖抗心律不齐剂和房性心律失常的预防（例如，心房纤维性颤动（AF）或心房扑动）。
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3.发明授权ARYLIERTE FURAN- UND THIOPHENCARBONSAUREAMIDE MIT KALIUM KANAL BLOCKIERENDER WIRKUNG 有权芳基化呋喃和THIOPHENCARBONSAUREAMIDE钾通道阻断作用
公开(公告)号：EP1349846B1
公开(公告)日：2005-02-09
申请号：EP01985832.3
申请日：2001-11-29
IPC分类号： C07D307/68 , C07D333/38 , A61K31/38 , A61K31/34 , A61P9/06
CPC分类号： C07D333/38 , A61K31/34 , A61K31/38 , C07D307/68 , A61K2300/00
摘要： The invention relates to arylated furane and thiophene carboxylic acid amides, a method for the production thereof, the use thereof as medicaments, in addition to pharmaceutical preparations containing the compounds of formula (Ia) and (Ib) wherein X, R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(30) and R(31) have the same meaning as cited in the claims. According to the invention, the compounds are particularly suitable as novel anti-arrhythmic active ingredients, particularly for the treatment and prophylaxis of atrial arrhythmia for example, atrial fibrillation, AF, or atrial flutter.
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4.发明公开INDANYLSUBSTITUIERTE BENZOLCARBONAMIDE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT SOWIE SIE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN 有权INDANYLSUBSTITUIERTE BENZOLCARBONAMIDE，工艺所周之，及其作为药物的用途和含有药物制剂
公开(公告)号：EP1194403A1
公开(公告)日：2002-04-10
申请号：EP00940359.3
申请日：2000-06-10
IPC分类号： C07C311/16 , C07D295/22 , C07C311/20 , C07C311/29 , C07C311/21 , C07D217/02 , C07C311/39 , A61K31/18 , A61K31/445
CPC分类号： C07D295/26 , C07C311/16 , C07C311/20 , C07C311/21 , C07C311/26 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D217/02
摘要： The invention relates to compounds of formula (I), wherein R(1) to R(8) have the meanings given in the claims. Said compounds act upon the Kv1.5 potassium canal and inhibit a potassium flux, known as an 'ultra-rapidly activating delayed rectifier' in the human atrium. The compounds are therefore particularly suitable for use as novel anti-arrhythmic active ingredients, in particular, for the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillation (AF) or atrial flutter.
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5.发明公开ARYLIERTE FURAN- UND THIOPHENCARBONSAUREAMIDE MIT KALIUM KANAL BLOCKIERENDER WIRKUNG 有权芳基化呋喃和THIOPHENCARBONSAUREAMIDE钾通道阻断作用
公开(公告)号：EP1349846A1
公开(公告)日：2003-10-08
申请号：EP01985832.3
申请日：2001-11-29
IPC分类号： C07D307/68 , C07D333/38 , A61K31/38 , A61K31/34 , A61P9/06
CPC分类号： C07D333/38 , A61K31/34 , A61K31/38 , C07D307/68 , A61K2300/00
摘要： The invention relates to arylated furane and thiophene carboxylic acid amides, a method for the production thereof, the use thereof as medicaments, in addition to pharmaceutical preparations containing the compounds of formula (Ia) and (Ib) wherein X, R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(30) and R(31) have the same meaning as cited in the claims. According to the invention, the compounds are particularly suitable as novel anti-arrhythmic active ingredients, particularly for the treatment and prophylaxis of atrial arrhythmia for example, atrial fibrillation, AF, or atrial flutter.
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6.发明公开ORTHO, META-SUBSTITUIERTE BISARYLVERBINDUNGEN, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT SOWIE SIE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN 有权邻，间位取代BISARYLVERBINDUNGEN，工艺所周之，及其作为药物的用途和含有药物制剂
公开(公告)号：EP1339675A1
公开(公告)日：2003-09-03
申请号：EP01989479.9
申请日：2001-11-17
IPC分类号： C07C271/22 , C07C235/34 , C07D213/79 , C07D213/81 , C07D213/82 , A61K31/325 , A61K31/4402 , A61K31/4406 , A61P9/06
CPC分类号： C07D213/79 , C07C235/34 , C07C271/22 , C07D213/81 , C07D213/82
摘要： The invention relates to compounds of formula (I), wherein A1 to A8, R(1), R(2), R(3), R(4), R(30) and R(31) have the meanings as cited in the patent claims. These compounds are especially well-suited for use as novel antiarrhythmic active substances, in particular, for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillations (AF) or atrial flutters.
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7.发明授权INDANYLSUBSTITUIERTE BENZOLCARBONAMIDE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT SOWIE SIE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN 有权INDANYLSUBSTITUIERTE BENZOLCARBONAMIDE，工艺所周之，及其作为药物的用途和含有药物制剂
公开(公告)号：EP1194403B1
公开(公告)日：2003-09-03
申请号：EP00940359.3
申请日：2000-06-10
IPC分类号： C07C311/16 , C07D295/22 , C07C311/20 , C07C311/29 , C07C311/21 , C07D217/02 , C07C311/39 , A61K31/18 , A61K31/445
CPC分类号： C07D295/26 , C07C311/16 , C07C311/20 , C07C311/21 , C07C311/26 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D217/02
摘要： The invention relates to compounds of formula (I), wherein R(1) to R(8) have the meanings given in the claims. Said compounds act upon the Kv1.5 potassium canal and inhibit a potassium flux, known as an 'ultra-rapidly activating delayed rectifier' in the human atrium. The compounds are therefore particularly suitable for use as novel anti-arrhythmic active ingredients, in particular, for the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillation (AF) or atrial flutter.
摘要翻译： 其中R（1）到R（8）具有在权利要求中所述的含义，在人的心房作用于对Kv1.5钾通道，和抑制钾电流，通过向称为“超快速激活延迟整流，” ， 它们特别适合用作因此是非常新颖的抗心律失常的活性物质，特别是用于治疗和房性心律失常的预防，E. G.，心房纤维性颤动或心房扑动。
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8.发明公开2'-SUBSTITUIERTE 1,1'-BIPHENYL-2-CARBOXAMIDE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT SOWIE SIE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN 有权2'-取代-1,1'-联苯-2-羧酰胺，PROCESS FOR THEIR，及其作为药物的用途和含有药物制剂
公开(公告)号：EP1222163A1
公开(公告)日：2002-07-17
申请号：EP00967703.0
申请日：2000-09-19
IPC分类号： C07C271/22 , C07D213/40 , C07C311/19 , C07C311/06 , C07C311/13 , C07C233/11 , C07C233/87 , C07C235/38 , C07C275/28 , C07C275/24 , C07C335/16 , C07C335/12 , C07D233/54 , A61K31/165 , A61P9/06
CPC分类号： C07D213/40 , C07C237/42 , C07C271/22 , C07C271/54 , C07C275/42 , C07C311/06 , C07C311/13 , C07C311/19 , C07C311/29 , C07C311/46 , C07C311/47 , C07C317/18 , C07C335/16 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D233/54
摘要： The invention relates to compounds of formula (I), wherein R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(8), R(30) and R(31) have the meanings cited in the Claims and are especially suitable as novel antiarrhythmic active agents, in particular for the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillations (AF) or atrial flutter.
摘要翻译： 本发明涉及式（I），worin R（1），R（2），R（3），R（4），R（5），R（6）R（7）R的化合物（8 （）R 30）和R（31）具有在权利要求中所引用的含义，并且是爱特别适合作为抗心律失常新颖活性剂，特别是用于治疗和房性心律失常的预防，例如 心房纤维性颤动（AF）或心房扑动。
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9.发明授权ORTHO, META-SUBSTITUIERTE BISARYLVERBINDUNGEN, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT SOWIE SIE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN 有权邻，间位取代BISARYLVERBINDUNGEN，工艺所周之，及其作为药物的用途和含有药物制剂
公开(公告)号：EP1339675B1
公开(公告)日：2005-02-16
申请号：EP01989479.9
申请日：2001-11-17
IPC分类号： C07C271/22 , C07C235/34 , C07D213/79 , C07D213/81 , C07D213/82 , A61K31/325 , A61K31/4402 , A61K31/4406 , A61P9/06
CPC分类号： C07D213/79 , C07C235/34 , C07C271/22 , C07D213/81 , C07D213/82
摘要： The invention relates to compounds of formula (I), wherein A1 to A8, R(1), R(2), R(3), R(4), R(30) and R(31) have the meanings as cited in the patent claims. These compounds are especially well-suited for use as novel antiarrhythmic active substances, in particular, for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillations (AF) or atrial flutters.
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10.发明公开ANTHRANILSÄUREAMIDE MIT HETEROARYLSULFONYL-SEITENKETTE UND IHRE VERWENDUNG ALS ANTIARRHYTHMISCHE WIRKSTOFFE 有权邻氨基WITH的杂侧链和它们作为抗心律失常活性
公开(公告)号：EP1399423A2
公开(公告)日：2004-03-24
申请号：EP02745333.1
申请日：2002-05-31
IPC分类号： C07D215/36 , A61K31/33 , A61P9/06 , C07D401/12 , C07D333/34 , C07D405/12 , C07D261/10 , C07D271/12 , C07D213/71
CPC分类号： C07D261/10 , A61K31/47 , A61K45/06 , C07D215/36 , C07D217/02 , C07D271/12 , C07D333/34 , C07D401/12 , C07D405/12 , A61K2300/00
摘要： The invention relates to compounds of formula (I), wherein R(1) -R(7) have the meanings cited in the claims. Said compounds act upon the Kv1.5-potassium channel and inhibit a potassium flow in the atrium of the human heart, designated as an ultra-rapidly activating delayed rectifier. As a result, they are particularly suitable for use as novel antiarrhythmic active substances, especially in the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillation (AF) or atrial flutter.
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