发明公开
EP1355892A1 2-AMINO-4-(PYRIDIN-2-YL)-THIAZOLE DERIVATIVES AS TRANSFORMING GROWTH FACTOR BETA (TGF-BETA) INHIBITORS
审中-公开
2-氨基-4-（吡啶-2-基）噻唑衍生物ALS抑制剂转化生长因子BET（TGF-βA）
- 专利标题： 2-AMINO-4-(PYRIDIN-2-YL)-THIAZOLE DERIVATIVES AS TRANSFORMING GROWTH FACTOR BETA (TGF-BETA) INHIBITORS
- 专利标题（中）： 2-氨基-4-（吡啶-2-基）噻唑衍生物ALS抑制剂转化生长因子BET（TGF-βA）
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申请号： EP02710053.6申请日： 2002-01-30
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公开(公告)号： EP1355892A1公开(公告)日： 2003-10-29
- 发明人: GELLIBERT, Francoise, Jeanne , HARTLEY, Charles, David , MATHEWS, Neil , WOOLVEN, James, Michael
- 申请人： GLAXO GROUP LIMITED
- 申请人地址： Glaxo Wellcome HouseBerkeley Avenue Greenford, Middlesex UB6 ONN GB
- 专利权人： GLAXO GROUP LIMITED
- 当前专利权人： GLAXO GROUP LIMITED
- 当前专利权人地址： Glaxo Wellcome HouseBerkeley Avenue Greenford, Middlesex UB6 ONN GB
- 代理机构： Sewell, Richard Charles
- 优先权： GB0102668 20010202
- 国际公布： WO02062776 20020815
- 主分类号： C07D277/42
- IPC分类号： C07D277/42 ; C07D417/14 ; A61K31/425 ; A61P1/16
摘要：
Therapeutically active thiazole derivatives of formula (I) wherein R1, R2, X and X' are as defined in the specification, processes for the preparation thereof, the use thereof in therapy, particularly in the treatment or prophylaxis of disorders characterised by overexpression of transforming growth factor β (TGF-β), and pharmaceutical compositions for use in such therapy. (I)
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