发明公开
- 专利标题： CARBOXYLIC ACIDS
- 专利标题（中）： CARBONSÄUREN
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申请号： EP02707188.5申请日： 2002-03-27
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公开(公告)号： EP1375484A1公开(公告)日： 2004-01-02
- 发明人: HARADA, Hitoshi , SHINODA, Masanobu , CLARK, Richard , MATSUURA, Fumiyoshi , EMORI, Eita , KASAI, Shunji , YOSHITOMI, Hideki , YAMAZAKI, Kazuto , INOUE, Takashi , MIYASHITA, Sadakazu , HIHARA, Taro
- 申请人： Eisai Co., Ltd.
- 申请人地址： 6-10, Koishikawa 4-chome, Bunkyo-ku Tokyo 112-8088 JP
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： 6-10, Koishikawa 4-chome, Bunkyo-ku Tokyo 112-8088 JP
- 代理机构： HOFFMANN - EITLE
- 优先权： JP2001091675 20010328
- 国际公布： WO2002079162 20021010
- 主分类号： C07D213/64
- IPC分类号： C07D213/64 ; A61K31/4409 ; A61K31/4412 ; A61P1/04 ; A61P3/06 ; A61P3/10 ; A61P29/00 ; A61P43/00
摘要：
The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them.
In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C 1-6 alkyl group or a C 1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III):
(wherein Z represents a group represented by the formula (IV):
(wherein R 9 , R 10 , R 11 and R 12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C 1-6 alkyl group or a C 1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.
In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C 1-6 alkyl group or a C 1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III):
(wherein Z represents a group represented by the formula (IV):
(wherein R 9 , R 10 , R 11 and R 12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C 1-6 alkyl group or a C 1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.
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