发明公开
EP1379530A4 PROCESS FOR THE SELECTIVE PREPARATION OF 3-(Z) PROPENYL-CEPHEM COMPOUND
审中-公开
用于3-（Z）选择性地制备过程-PROPENYLCEPHEMVERBINDUNG
- 专利标题： PROCESS FOR THE SELECTIVE PREPARATION OF 3-(Z) PROPENYL-CEPHEM COMPOUND
- 专利标题（中）： 用于3-（Z）选择性地制备过程-PROPENYLCEPHEMVERBINDUNG
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申请号： EP02720650申请日： 2002-04-17
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公开(公告)号： EP1379530A4公开(公告)日： 2008-04-02
- 发明人: LEE GWAN SUN , CHANG YOUNG KIL , KIM HONG SUN , LEE JAE HEON , PARK CHUL HYUN , PARK GHA SEUNG , KIM CHEOL KYUNG
- 申请人： HANMI PHARM IND CO LTD
- 专利权人： HANMI PHARM IND CO LTD
- 当前专利权人： HANMI PHARM IND CO LTD
- 优先权： KR20010020673 2001-04-18
- 主分类号： C07D501/22
- IPC分类号： C07D501/22 ; A61K31/545 ; A61P31/04 ; C07D501/00 ; C07D501/04
摘要：
A 3-(Z)-propenyl cephem compound is selectively prepared by reacting a phosphoranylidene cephemcompound with acetaldehyde in the presence of a base in a solvent mixture comprising diethyl ether, formula (I), wherein R is a carboxyl protecting group; R1 is hydrogen or R2CH2CO-; and R2 is ethyl, 2-thiophenyl, phenyl, p-hydroxyphenyl or phenoxy.
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