发明公开
EP1384711A1 Optical resolution of a piperidine derivative
失效
Optische Trennung eines Piperidin-Derivates
- 专利标题： Optical resolution of a piperidine derivative
- 专利标题（中）： Optische Trennung eines Piperidin-Derivates
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申请号： EP03077856.7申请日： 1997-05-29
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公开(公告)号： EP1384711A1公开(公告)日： 2004-01-28
- 发明人: Sugi, Kiyoshi, Sumika Fine Chemicals Co., Ltd. , Itaya, Nobushige, Sumika Fine Chemicals Co., Ltd. , Katsura, Tadashi, Sumika Fine Chemicals Co., Ltd. , Igi, Masami, Sumika Fine Chemicals Co., Ltd. , Yamazaki, Shigeya, Sumika Fine Chemicals Co., Ltd. , Ishibashi, Taro, Sumika Fine Chemicals Co., Ltd. , Yamaoka, Teiji, Sumika Fine Chemicals Co., Ltd. , Kawada, Yoshihiro, Sumika Fine Chemicals Co., Ltd. , Tagami, Yayoi, Sumika Fine Chemicals Co., Ltd.
- 申请人： SUMIKA FINE CHEMICALS Co., Ltd.
- 申请人地址： 1-21, Utajima 3-chome Nishi Yodogawa-ku, Osaka-shi, Osaka JP
- 专利权人： SUMIKA FINE CHEMICALS Co., Ltd.
- 当前专利权人： SUMIKA FINE CHEMICALS Co., Ltd.
- 当前专利权人地址： 1-21, Utajima 3-chome Nishi Yodogawa-ku, Osaka-shi, Osaka JP
- 代理机构： Gillard, Richard Edward
- 优先权： JP17589396 19960613; JP29458596 19961015; JP30383896 19961029; JP32617796 19961120; JP5098097 19970218
- 主分类号： C07D211/22
- IPC分类号： C07D211/22 ; C07B57/00
摘要：
The present invention relates to a method for preparing (3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine represented by the formula (II):
The method comprises the step of optically resolving (3SR,4RS)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine with o-chlorotartranilic acid as an optically active organic acid.
The method comprises the step of optically resolving (3SR,4RS)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine with o-chlorotartranilic acid as an optically active organic acid.
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