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1.发明公开Process for preparing 2-cyanobiphenyl compound 失效Verfahren zur Herstellung von 2-Cyanobiphenyl Verbindungen
公开(公告)号：EP0953564A1
公开(公告)日：1999-11-03
申请号：EP99200951.4
申请日：1998-01-21
发明人： Katsura, Tadashi, Sumika Fine Chemicals Co., Ltd. , Shiratani, Hiroshi, Sumika Fine Chem. Co., Ltd. , Sugi, Kiyoshi, Sumika Fine Chemicals Co., Ltd. , Itaya, Nobushige, Sumika Fine Chemicals Co., Ltd.
IPC分类号： C07C253/30
CPC分类号： C07C253/30 , C07C255/50
摘要： A process for preparing a 2-cyanobiphenyl compound represented by the formula (II):
wherein R 1 is an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, or hydrogen atom, from a phenylmagnesium chloride compound represented by the formula (I):
wherein R 1 is as defined above. According to the process, a 2-cyanobiphenyl compound represented by the formula (II) can be economically, simply, industrially and advantageously prepared.摘要翻译： 制备由式（II）表示的2-氰基联苯化合物的方法：其中R 1是具有1至6个碳原子的烷基，具有1至6个碳原子的烷氧基或氢原子的
由式（I）表示的苯基氯化镁化合物：其中R 1如上定义。 根据该方法，由式（II）表示的2-氰基联苯化合物可以在经济上简单地在工业上有利地制备。 -
公开(公告)号：EP1384720A1
公开(公告)日：2004-01-28
申请号：EP03077858.3
申请日：1997-05-29
发明人： Sugi, Kiyoshi, Sumika Fine Chemicals Co., Ltd. , Itaya, Nobushige, Sumika Fine Chemicals Co., Ltd. , Katsura, Tadashi, Sumika Fine Chemicals Co., Ltd. , Igi, Masami, Sumika Fine Chemicals Co., Ltd. , Yamazaki, Shigeya, Sumika Fine Chemicals Co., Ltd. , Ishibashi, Taro, Sumika Fine Chemicals Co., Ltd. , Yamaoka, Teiji, Sumika Fine Chemicals Co., Ltd. , Kawada, Yoshihiro, Sumika Fine Chemicals Co., Ltd. , Tagami, Yayoi, c/o Sumika Fine Chemicals Co., Ltd.
IPC分类号： C07D405/12
CPC分类号： C07D405/12 , C07D211/22 , C07D211/60 , C07D211/76
摘要： The present invention relates to a method for drying paroxetine hydrochloride containing 8 to 15% by weight of isopropanol. The method comprises the steps of:
(1) drying crystals of paroxetine hydrochloride containing 8 to 15% by weight of isopropanol obtained by the precipitation of crystals of paroxetine hydrochloride from an isopropanol solution of paroxetine hydrochloride, under reduced pressure at 70°C, and
(2) drying the resulting paroxetine hydrochloride under a reduced pressure at a temperature of from 80° to 110°C to give paroxetine hydrochloride having an isopropanol content of 0.1 to 5% by weight.摘要翻译： 本发明涉及含有8〜15重量％异丙醇的盐酸帕罗西汀盐酸盐的方法。 该方法包括以下步骤：（1）在70℃减压下，将盐酸帕罗西汀含有盐酸帕罗西汀异丙醇溶液沉淀得到的异丙醇8〜15重量％的结晶， （2）在80〜110℃的温度下减压干燥得到的盐酸帕罗西汀盐酸盐，得到异丙醇含量为0.1〜5重量％的盐酸帕罗西汀。
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3.发明公开
公开(公告)号：EP1384711A1
公开(公告)日：2004-01-28
申请号：EP03077856.7
申请日：1997-05-29
发明人： Sugi, Kiyoshi, Sumika Fine Chemicals Co., Ltd. , Itaya, Nobushige, Sumika Fine Chemicals Co., Ltd. , Katsura, Tadashi, Sumika Fine Chemicals Co., Ltd. , Igi, Masami, Sumika Fine Chemicals Co., Ltd. , Yamazaki, Shigeya, Sumika Fine Chemicals Co., Ltd. , Ishibashi, Taro, Sumika Fine Chemicals Co., Ltd. , Yamaoka, Teiji, Sumika Fine Chemicals Co., Ltd. , Kawada, Yoshihiro, Sumika Fine Chemicals Co., Ltd. , Tagami, Yayoi, Sumika Fine Chemicals Co., Ltd.
IPC分类号： C07D211/22 , C07B57/00
CPC分类号： C07D405/12 , C07D211/22 , C07D211/60 , C07D211/76
摘要： The present invention relates to a method for preparing (3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine represented by the formula (II):
The method comprises the step of optically resolving (3SR,4RS)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine with o-chlorotartranilic acid as an optically active organic acid.摘要翻译： 本发明涉及一种制备式（II）表示的（3S，4R） - 反式-4-（4-氟苯基）-3-羟甲基哌啶的方法：该方法包括光学拆分（3SR， 4RS） - 反式-4-（4-氟苯基）-3-羟甲基哌啶与邻氯邻氨基苯甲酸作为光学活性有机酸。
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4.发明公开Process for preparing crystalline paroxetin hydrochloride 失效Verfahren zur Herstellung von kristallinem Paroxetin-Hydrochlorid
公开(公告)号：EP1394160A1
公开(公告)日：2004-03-03
申请号：EP03077857.5
申请日：1997-05-29
发明人： Sugi, Kiyoshi, Sumika Fine Chemicals Co., Ltd. , Itaya, Nobushige, Sumika Fine Chemicals Co., Ltd. , Katsura, Tadashi, Sumika Fine Chemicals Co., Ltd. , Igi, Masami, Sumika Fine Chemicals Co., Ltd. , Yamazaki, Shigeya, Sumika Fine Chemicals Co., Ltd. , Ishibashi, Taro, Sumika Fine Chemicals Co., Ltd. , Yamaoka, Teiji, Sumika Fine Chemicals Co., Ltd. , Kawada, Yoshihiro, Sumika Fine Chemicals Co., Ltd. , Tagami, Yayoi, Sumika Fine Chemicals Co., Ltd.
IPC分类号： C07D405/12 , C07D211/22
CPC分类号： C07D405/12 , C07D211/22 , C07D211/60 , C07D211/76
摘要： The present invention relates to a method for obtaining crystals of paroxetine hydrochloride containing isopropanol. The method comprises the step of adding seed crystals of paroxetine hydrochloride containing isopropanol to an isopropanol solution of paroxetine hydrochloride, preferably at a temperature of from 45° to 50°C, to afford crystalline paroxetine hydrochloride.
摘要翻译： 本发明涉及一种获得含异丙醇的盐酸帕罗西汀晶体的方法。 该方法包括将盐酸帕罗西汀盐酸盐的晶体加入到盐酸帕罗西汀的异丙醇溶液中，优选在45℃至50℃的温度下加入盐酸帕罗西汀结晶的步骤。
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公开(公告)号：EP1050526B1
公开(公告)日：2003-07-16
申请号：EP00303799.1
申请日：2000-05-05
发明人： Shintaku, Tetsuya, Sumika Fine Chemicals Co., Ltd. , Sugi, Kiyoshi, Sumika Fine Chemicals Co., Ltd. , Katsura, Tadashi, Sumika Fine Chemicals Co., Ltd. , Itaya, Nobushige, Sumika Fine Chemicals Co., Ltd.
IPC分类号： C07C67/04 , C07C69/63 , C07C255/19 , C07C253/30
CPC分类号： C07C253/30 , C07C67/04 , C07C69/63 , C07C255/19
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公开(公告)号：EP0953564B1
公开(公告)日：2001-06-13
申请号：EP99200951.4
申请日：1998-01-21
发明人： Katsura, Tadashi, Sumika Fine Chemicals Co., Ltd. , Shiratani, Hiroshi, Sumika Fine Chem. Co., Ltd. , Sugi, Kiyoshi, Sumika Fine Chemicals Co., Ltd. , Itaya, Nobushige, Sumika Fine Chemicals Co., Ltd.
IPC分类号： C07C253/30
CPC分类号： C07C253/30 , C07C255/50
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