发明公开
- 专利标题： GASTRIN-RECEPTOR-AVID PEPTIDE CONJUGATES
- 专利标题（中）： 肽缀合物具有亲和力的胃泌素受体
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申请号： EP02725889.6申请日： 2002-04-30
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公开(公告)号： EP1385556A1公开(公告)日： 2004-02-04
- 发明人: HOFFMAN, Timothy, J. , VOLKERT, Wynn, A. , SIECKMAN, Gary , HIGGINBOTHAM, Chrys-Ann , LI, Ning , GALI, Hariprasad , SMITH, Charles, J.
- 申请人： University of Missouri System at Columbia , Hoffman, Timothy J. , Volkert, Wynn A. , Sieckman, Gary , Higginbotham, Chrys-Ann , Li, Ning
- 申请人地址： 615 Locust Street Building,Third Floor Columbia, MO 65211-1400 US
- 专利权人： University of Missouri System at Columbia,Hoffman, Timothy J.,Volkert, Wynn A.,Sieckman, Gary,Higginbotham, Chrys-Ann,Li, Ning
- 当前专利权人： University of Missouri System at Columbia,Hoffman, Timothy J.,Volkert, Wynn A.,Sieckman, Gary,Higginbotham, Chrys-Ann,Li, Ning
- 当前专利权人地址： 615 Locust Street Building,Third Floor Columbia, MO 65211-1400 US
- 代理机构： Jacob, Reuben Ellis
- 优先权： US847134 20010502
- 国际公布： WO2002087631 20021107
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; A61M36/14
摘要：
A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.
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