公开(公告)号：EP1385556A1

公开(公告)日：2004-02-04

申请号：EP02725889.6

申请日：2002-04-30

申请人： University of Missouri System at Columbia ,  Hoffman, Timothy J. ,  Volkert, Wynn A. ,  Sieckman, Gary ,  Higginbotham, Chrys-Ann ,  Li, Ning

发明人： HOFFMAN, Timothy, J. ,  VOLKERT, Wynn, A. ,  SIECKMAN, Gary ,  HIGGINBOTHAM, Chrys-Ann ,  LI, Ning ,  GALI, Hariprasad ,  SMITH, Charles, J.

IPC分类号： A61K51/00 ,  A61M36/14

CPC分类号： A61K51/088

摘要： A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.

公开(公告)号：EP0738110A1

公开(公告)日：1996-10-23

申请号：EP95907345.0

申请日：1995-01-03

申请人： UNIVERSITY OF MISSOURI SYSTEM AT COLUMBIA

发明人： VANDEPOPULIERE, Joseph, M. ,  COTTERILL, Owen, J.

IPC分类号： A23B5

CPC分类号： A23B5/0052 ,  A23B5/005

摘要： The present invention relates to producing a safer shell egg through thermal treatment. The present invention provides methods of producing a shell egg wherein the albumen and the yolk of the shell egg receives a thermal treatment sufficient to pasteurize the shell egg and thereby combat the risk of salmonella. The present invention provides methods of providing thermal treatments to the shell egg through introduction of the shell egg into an aqueous solution of a predetermined temperature and maintaining the shell egg in the solution for a predetermined time sufficient to cause the required reduction in salmonella. The predetermined times and temperatures may be characterized by use of the equivalent point method of thermal evaluation, by use of the Fo line for shell egg or by other methods of determining the reduction in salmonella.

公开(公告)号：EP0738110B1

公开(公告)日：2004-10-13

申请号：EP95907345.3

申请日：1995-01-03

申请人： UNIVERSITY OF MISSOURI SYSTEM AT COLUMBIA

发明人： VANDEPOPULIERE, Joseph, M. ,  COTTERILL, Owen, J.

IPC分类号： A23B5/005

CPC分类号： A23B5/0052 ,  A23B5/005