发明公开
EP1394160A1 Process for preparing crystalline paroxetin hydrochloride
失效
Verfahren zur Herstellung von kristallinem Paroxetin-Hydrochlorid
- 专利标题： Process for preparing crystalline paroxetin hydrochloride
- 专利标题（中）： Verfahren zur Herstellung von kristallinem Paroxetin-Hydrochlorid
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申请号： EP03077857.5申请日： 1997-05-29
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公开(公告)号： EP1394160A1公开(公告)日： 2004-03-03
- 发明人: Sugi, Kiyoshi, Sumika Fine Chemicals Co., Ltd. , Itaya, Nobushige, Sumika Fine Chemicals Co., Ltd. , Katsura, Tadashi, Sumika Fine Chemicals Co., Ltd. , Igi, Masami, Sumika Fine Chemicals Co., Ltd. , Yamazaki, Shigeya, Sumika Fine Chemicals Co., Ltd. , Ishibashi, Taro, Sumika Fine Chemicals Co., Ltd. , Yamaoka, Teiji, Sumika Fine Chemicals Co., Ltd. , Kawada, Yoshihiro, Sumika Fine Chemicals Co., Ltd. , Tagami, Yayoi, Sumika Fine Chemicals Co., Ltd.
- 申请人： SUMIKA FINE CHEMICALS Co., Ltd.
- 申请人地址： 1-21, Utajima 3-chome Nishi Yodogawa-ku, Osaka-shi, Osaka JP
- 专利权人： SUMIKA FINE CHEMICALS Co., Ltd.
- 当前专利权人： SUMIKA FINE CHEMICALS Co., Ltd.
- 当前专利权人地址： 1-21, Utajima 3-chome Nishi Yodogawa-ku, Osaka-shi, Osaka JP
- 代理机构： Gillard, Richard Edward
- 优先权： JP17589396 19960613; JP29458596 19961015; JP30383896 19961029; JP32617796 19961120; JP5098097 19970218
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; C07D211/22
摘要：
The present invention relates to a method for obtaining crystals of paroxetine hydrochloride containing isopropanol. The method comprises the step of adding seed crystals of paroxetine hydrochloride containing isopropanol to an isopropanol solution of paroxetine hydrochloride, preferably at a temperature of from 45° to 50°C, to afford crystalline paroxetine hydrochloride.
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