发明公开
- 专利标题： COMPOSITIONS AND METHODS RELATING TO OSTEOARTHRITIS
- 专利标题（中）： 组合物和方法与之相关指骨性关节炎
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申请号： EP02703416.4申请日： 2002-02-28
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公开(公告)号： EP1404868A2公开(公告)日： 2004-04-07
- 发明人: LIEW, Choong-Chin , MARSHALL, Wayne, E. , ZHANG, Hongwei
- 申请人： Chondrogene Inc.
- 申请人地址： 800 Petrolia Road,Unit 15 Toronto,Ontario M3J 3K4 CA
- 专利权人： Chondrogene Inc.
- 当前专利权人： Chondrogene Inc.
- 当前专利权人地址： 800 Petrolia Road,Unit 15 Toronto,Ontario M3J 3K4 CA
- 代理机构： Thurgood, Alexander John
- 优先权： US271955P 20010228; US275017P 20010312; US305340P 20010713
- 国际公布： WO2002070737 20020912
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
The invention provides for one or more polynucleotide sequences that are expressed in chondrocytes from any of the following developmental and disease stages: fetal, normal, mild, ostearthritic, moderate osteoarthritic, marked and osteoarthritic. The invention also relates to arrays and compositions comprising any combination of these polynucleotide sequences. The invention also provides for methods of using the arrays of the invention to diagnose osteoarthritis. The invention also provides for methods of identifying therapeutic agents that alter the level of expression of the polynucleotides of the invention or alter the anabolic level of a chondrocyte.
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