摘要:
The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (p m ) and the total number of amino acid residues (r) wherein 3p m is the largest number that is less than or equal to r + 1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (p t ) wherein 2a is the largest number that is less than or equal to p t + 1, except that when a is 1, p t may also be 1.
摘要:
The invention provides a water soluble complex comprising an inner core of a metal or semi-conductor nanoparticle. The nanoparticle is coated with a hydrophobic ligand, which is encapsulated in a micelle. In an aqueous medium, the micelle comprises a hydrophilic shell and a hydrophobic core, the hydrophilic shell comprising a plurality of hydrophilic moieties, the hydrophobic core comprising a plurality of hydrophobic moieties, each hydrophobic moiety comprising at least one chain, each chain comprising a minimum of 8 atoms; wherein the total number of atoms in all chains for each moiety comprises at least 24 atoms. The micelle has a minimum average diameter of approximately 5 nm and a maximum average diameter of approximately 45 nm.
摘要:
The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.
摘要:
The invention relates to a blind rivet (R) characterised in that it comprises a severing groove (130) shaped in such a way that the connection between the bottom of the groove and the outside diameter of the mandrel (100) increases more on the shank side than on the head side; a shank (120) provided with a plurality of preformed crimping grooves (140) and shaped in such a way that once the shank has been severed at the severing groove (130), part of the crimping grooves (140) extends beyond the sleeve (200); at least one weakening groove (150) on the shank; a crimping collar insert (400) is crimped into the crimping grooves (140) extending beyond the sleeve (200) using a tool (500) provided with a setting tip which can exert a pulling force on the mandrel (100) in order to bend the sleeve (200) and crimp the collar (400) on the mandrel (100). The invention is useful for attachment and riveting.
摘要:
This invention pertains to a soft contact lens that has a body with a central zone aligned with the optical axis of the eye when a wearer wears the lens, In one embodiment the soft lens includes a chamber 17 that extends from a lower portion of the lens to its central axis and arranged so that when a person looks down, a fluid is squeezed from the reservoir 9 and changes the optical characteristics of the lens.