发明公开
- 专利标题： SULPHONYL ARYL HYDROXAMATES AND THEIR USE AS MMP INHIBITORS
- 专利标题（中）： 磺酰基异羟肟酸芳基和它们作为MMP抑制剂
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申请号： EP02761148.2申请日： 2002-07-19
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公开(公告)号： EP1406626A2公开(公告)日： 2004-04-14
- 发明人: MCDONALD, Joseph, J. , BARTA, Thomas, E. , BECKER, Daniel, P. , BEDELL, Louis, J. , RAO, Shashidhar, N. , FRESKOS, John, N. , DE CRESCENZO, Gary, A. , MISCHKE, Brent, V. , GETMAN, Daniel, P. , VILLAMIL, Clara, I.
- 申请人： Pharmacia Corporation
- 申请人地址： 800 North Lindbergh Boulevard,Mail Zone 04E St. Louis, MO 63167 US
- 专利权人： Pharmacia Corporation
- 当前专利权人： Pharmacia Corporation
- 当前专利权人地址： 800 North Lindbergh Boulevard,Mail Zone 04E St. Louis, MO 63167 US
- 代理机构： Stuart, Peter Graham
- 优先权： US909227 20010719
- 国际公布： WO2003007954 20030130
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; A61K31/40 ; A61K31/4409 ; A61K31/485 ; A61K31/18 ; C07D211/96 ; C07C317/24 ; C07D207/48 ; C07D401/12 ; C07D235/22 ; C07D401/04 ; C07D405/12 ; C07D409/12 ; A61P1/16 ; A61P19/02 ; A61P19/00
摘要：
The invention is directed to sulfonyl aromatic hydroxamic acid compounds and salts thereof that, inter alia, inhibit matrix metalloprotease (MMP) activity and/or aggrecanase activity. In some particularly preferred embodiments, the compound corresponds in structure to one of the following formulas: (I) (II) wherein W2, the R groups, and -A-R-E-Y are described in more detail in Applicants'specification. This invention also is directed to a process that comprises administering such a compound or pharmaceutically acceptable salt thereof to a host animal having a condition associated with MMP activity.
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