-
1.发明公开
公开(公告)号：EP1562928A1
公开(公告)日：2005-08-17
申请号：EP03783118.7
申请日：2003-11-03
发明人： AWASTHI, Alok, K. , BARTA, Thomas, E. , BECKER, Daniel, P. , BEDELL, Louis, J. , BOEHM, Terri, L. , CARROLL, Jeffery, N. , CHANDRAKUMAR, Nizal, S. , DECRESCENZO, Gary, A. , DESAI, Bipinchandra, N. , FOBIAN, Yvette, M. , FRESKOS, John, N. , HERON, Marcia, I. , HOCKERMAN, Susan, L. , JULL, Sara M. , KASSAB, Darren, J. , KOLODZIEJ, Stephen, A. , MCDONALD, Joseph, J. , MISCHKE, Deborah, A. , MULLINS, Patrick, B. , NORTON, Monica B. , RICO, Joseph G. , TALLEY, John J. , TRIVEDI, Mahima , VILLAMIL, Clara I. , WANG, Lijuan J.
IPC分类号： C07D309/08 , C07D211/06 , C07D405/12 , C07D401/12 , C07D407/12 , C07D417/12 , C07D413/12 , C07D409/12 , A61K31/4465 , A61P25/00
CPC分类号： C07D401/12 , A61K31/351 , A61K31/41 , A61K31/453 , A61K31/454 , C07D211/66 , C07D309/08 , C07D309/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/04
摘要： This invention is directed to aromatic sulfone hydroxamic acids (including aromatic sulfone hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as 'matrix metalloprotease' or 'MMP') activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.
-
2.发明公开AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS 审中-公开芳香SULFONHYDROXAMSÄUREN及其使用蛋白酶抑制剂
公开(公告)号：EP1472244A1
公开(公告)日：2004-11-03
申请号：EP02789749.5
申请日：2002-11-19
发明人： BARTA, Thomas, E. , BECKER, Daniel, P. , BEDELL, Louis, J. , BOEHM, Terri, L. , CARROLL, Jeffery, N. , DECRESCENZO, Gary, A. , FOBIAN, Yvette, M. , FRESKOS, John, N. , GETMAN, Daniel, P. , HOCKERMAN, Susan, L. , HOWARD, Carol, Pearcy , KASSAB, Darren, J. , KOLODZIEJ, Steve, A. , LI, Madeleine, H. , MCDONALD, Joseph, J. , MISCHKE, Deborah, A. , RICO, Joseph, G. , STEHLE, Nathan, W. , TOLLEFSON, Michael, B. , VILLAMIL, Clara, I.
IPC分类号： C07D405/12 , C07D405/14 , C07D409/12 , C07D335/02 , C07D211/66 , C07D401/12 , C07D417/06 , C07D417/12 , C07D413/12
CPC分类号： C07D401/14 , C07D211/66 , C07D231/12 , C07D233/56 , C07D249/08 , C07D309/08 , C07D335/02 , C07D401/06 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： This invention is directed to aromatic sulfone hydroxamates (also known as aromatic sulfone hydroxamic acids) and salts thereof that, inter alia, tend to inhibit matrix metalloproteinase (also known as matrix metalloprotease or MMP) activity and/or aggrecanase activity. This invention also is directed to a treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP activity and/or aggrecanase activity.
-
3.发明公开ARYLSULFONYLHYDROXAMIC ACID AND AMIDE DERIVATIVES AND THEIR USE AS PROTEASE INHIBITORS 审中-公开作者芳基磺酰基异羟肟酸和酰胺和它们作为蛋白酶抑制剂衍生物
公开(公告)号：EP1515951A1
公开(公告)日：2005-03-23
申请号：EP03742193.0
申请日：2003-06-25
发明人： CHEN, Yiyuan , FRESKOS, John, N. , GASIECKI, Alan, F. , GRAPPERHAUS, Margaret, L. , HANSEN, Donald, W., Jr. , HEINTZ, Robert, M. , KHANNA, Ish, K. , KOLODZIEJ, Steve, A. , MANTEGANI, Sergio , MASSA, Mark, A. , MCDONALD, Joseph, J. , MISCHKE, Deborah, A. , NAGY, Mark, A. , PERRONE, Ettore , SCHMIDT, Michelle, A. , SPANGLER, Dale, P. , TALLEY, John, J. , TRIVEDI, Mahima , WYNN, Thomas, A. , RICO, Joseph, G.
IPC分类号： C07D213/34 , C07D211/66 , C07D335/02 , C07D309/08 , C07D405/12 , A61K31/33 , C07C317/24 , A61K31/16
CPC分类号： C07D241/12 , C07C317/46 , C07D211/66 , C07D213/34 , C07D309/08 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： This invention is directed generally to hydroxamic acid and amide compounds (including salts of such compounds), and, more particularly, to aryl- and heteroaryl-arylsulfonylmethyl hydroxamic acids and amides that, inter alia, inhibit protease activity, particularly matrix metalloproteinase (also known as 'matrix metalloprotease' or 'MMP') activity and/or aggrecanase activity. These compounds generally correspond in structure to formula (I): wherein Al, A2, A3, El, E2, E3, and E4 are as defined in this patent. This invention also is directed to compositions of such compounds, intermediates for the syntheses of such compounds, methods for making such compounds, and methods for treating conditions associated with MMP activity and/or aggrecanase activity, particularly pathological conditions.
-
公开(公告)号：EP1406626A2
公开(公告)日：2004-04-14
申请号：EP02761148.2
申请日：2002-07-19
发明人： MCDONALD, Joseph, J. , BARTA, Thomas, E. , BECKER, Daniel, P. , BEDELL, Louis, J. , RAO, Shashidhar, N. , FRESKOS, John, N. , DE CRESCENZO, Gary, A. , MISCHKE, Brent, V. , GETMAN, Daniel, P. , VILLAMIL, Clara, I.
IPC分类号： A61K31/445 , A61K31/40 , A61K31/4409 , A61K31/485 , A61K31/18 , C07D211/96 , C07C317/24 , C07D207/48 , C07D401/12 , C07D235/22 , C07D401/04 , C07D405/12 , C07D409/12 , A61P1/16 , A61P19/02 , A61P19/00
CPC分类号： C07D295/26 , C07C311/16 , C07C311/21 , C07C317/22 , C07C317/44 , C07C323/65 , C07D207/14 , C07D207/16 , C07D207/48 , C07D211/16 , C07D211/18 , C07D211/46 , C07D211/54 , C07D211/62 , C07D211/96 , C07D213/30 , C07D213/82 , C07D295/15 , C07D309/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The invention is directed to sulfonyl aromatic hydroxamic acid compounds and salts thereof that, inter alia, inhibit matrix metalloprotease (MMP) activity and/or aggrecanase activity. In some particularly preferred embodiments, the compound corresponds in structure to one of the following formulas: (I) (II) wherein W2, the R groups, and -A-R-E-Y are described in more detail in Applicants'specification. This invention also is directed to a process that comprises administering such a compound or pharmaceutically acceptable salt thereof to a host animal having a condition associated with MMP activity.
-
5.发明公开USE OF SULFONYL ARYL OR HETEROARYL HYDROXAMIC ACIDS AND DERIVATIVES THEREOF AS AGGRECANASE INHIBITORS 审中-公开SULFONYLARYL-或杂芳羟肟及其衍生物用途作为抑制剂蛋白聚糖
公开(公告)号：EP1406602A2
公开(公告)日：2004-04-14
申请号：EP02763298.3
申请日：2002-07-19
发明人： MCDONALD, Joseph, J. , BARTA, Thomas, A. , ARNER, Elizabeth , BOEHM, Terri, L. , BECKER, Daniel, P. , DECRESCENZO, Gary, A.
IPC分类号： A61K31/166 , A61P19/00 , A61P19/02 , A61P35/00
CPC分类号： A61K31/18 , A61K31/16 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/4965
摘要： This invention is directed to a process for inhibiting aggrecanase activity. The process comprises administering a therapeutically effective amount of a sulfonyl aromatic or heteroaromatic hydroxamic acid, a derivative thereof, or a pharmaceutically acceptable salt of the hydroxamic acid or derivative to a host animal. The compound generally corresponds in structure to the following formula: , wherein W and the R groups are described in more detail in Applicants' specification.
-
6.发明公开PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS 审中-公开哌啶基和PIPERAZINYLSULFONYLMETHYLHYDROXAMSÄUREN及其作为蛋白酶抑制剂
公开(公告)号：EP1689743A2
公开(公告)日：2006-08-16
申请号：EP04810297.4
申请日：2004-11-03
发明人： BROWN, David, L. , GRAPPERHAUS, Margaret, L. , KASSAB, Darren, J. , MASSA, Mark, A. , MCDONALD, Joseph, J. , MULLINS, Patrick, B. , RICO, Joseph, G. , SCHMIDT, Michelle, A.
IPC分类号： C07D407/12
CPC分类号： C07D401/14 , C07D211/66 , C07D211/96 , C07D309/08 , C07D401/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to formula (I); (wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.
-
7.发明公开HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS 审中-公开HETEROARYLSULFONYLMETHYLHYDROXAMSÄUREN和酰胺及其作为蛋白酶抑制剂
公开(公告)号：EP1565459A2
公开(公告)日：2005-08-24
申请号：EP03812052.3
申请日：2003-11-24
发明人： BECKER, Daniel, P. , CARROLL, Jeffery, N. , FOBIAN, Yvette, M. , GRAPPERHAUS, Margaret, L. , HANSEN, Donald, W., Jr. , HEINTZ, Robert, M. , KASSAB, Darren, J. , MASSA, Mark, A. , MCDONALD, Joseph, J. , NAGY, Mark, A. , PITZELE, Barnett, S. , RICO, Joseph, G. , SCHMIDT, Michelle, A. , SPANGLER, Dale, P.
IPC分类号： C07D409/00
CPC分类号： C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： This invention is directed generally to heteroarylsulfonylmethyl hydroxamic acids and amides that, inter alia, tend to inhibit protease activity, particularly matrix metalloproteinase (also known as 'matrix metalloprotease' or 'MMP') activity and/or aggrecanase activity. This invention also is directed to compositions of such compounds; intermediates for the syntheses of such compounds; methods for making such compounds; and methods for treating conditions associated with MMP, tumor necrosis factors (or 'TNFs'), and/or aggrecanase activity, particularly pathological conditions.
-
8.发明公开AROMATIC SULFONYL ALPHA-CYCLOAMINO HYDROXAMATES AND THEIR USE AS MMP INHIBITORS 审中-公开芳香族磺酰ALPHA-环状氨基 - 异羟肟酸及其作为MMP抑制剂
公开(公告)号：EP1358155A1
公开(公告)日：2003-11-05
申请号：EP02720921.2
申请日：2002-02-07
发明人： BECKER, Daniel, P. , VILLAMIL, Clara, I. , LI, Madeleine, H. , BOEHM, Terri, L. , GETMAN, Daniel, P. , MCDONALD, Joseph, J. , DECRESCENZO, Gary, A.
IPC分类号： C07D207/16 , A61K31/401 , A61P19/00 , A61P25/28 , A61P35/04
CPC分类号： C07D207/16
摘要： This invention is directed to aromatic sulfonyl α-cycloamino hydroxamates (also known as aromatic sulfonyl α-cycloamino hydroxamic acids) of formula (I) that, inter alia, inhibit matrix metalloproteinase (also known as matrix metalloprotease or MMP) activity. This invention also is directed to a prevention or treatment method that comprises administering an aromatic sulfonyl α-cycloamino hydroxamate in an MMP-inhibiting effective amount to a mammal having (or disposed to having) a pathological condition associated with MMP activity.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.027 秒)
