发明公开
EP1406629A1 METHOD FOR INDUCING ANALGESIA COMPRISING ADMINISTRATION ALTERNATIVELY OF AN OPIOID RECEPTOR AGONIST AND AN OPIOID RECEPTOR LIKE RECEPTOR 1 AGONIST FOR AND AN IMPLANTABLE INFUSION PUMP
审中-公开
诱导含镇痛的替代阿片REZEPTORAGONISTS的管理和类似的阿片受体-1 REZEPTORAGONISTS的方法和输注泵IMPLANTABLE
- 专利标题： METHOD FOR INDUCING ANALGESIA COMPRISING ADMINISTRATION ALTERNATIVELY OF AN OPIOID RECEPTOR AGONIST AND AN OPIOID RECEPTOR LIKE RECEPTOR 1 AGONIST FOR AND AN IMPLANTABLE INFUSION PUMP
- 专利标题（中）： 诱导含镇痛的替代阿片REZEPTORAGONISTS的管理和类似的阿片受体-1 REZEPTORAGONISTS的方法和输注泵IMPLANTABLE
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申请号： EP02721261.2申请日： 2002-02-28
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公开(公告)号： EP1406629A1公开(公告)日： 2004-04-14
- 发明人: DEMOPULOS, Gregory, A. , PALMER, Pamela, Pierce
- 申请人： Omeros Corporation , The Regents of The University of California
- 申请人地址： 1420 Fifth Avenue,Suite 2675 Seattle, WA 98101 US
- 专利权人： Omeros Corporation,The Regents of The University of California
- 当前专利权人： Omeros Corporation,The Regents of The University of California
- 当前专利权人地址： 1420 Fifth Avenue,Suite 2675 Seattle, WA 98101 US
- 代理机构： Williams, Richard Andrew Norman
- 优先权： US302796P 20010702
- 国际公布： WO2003004034 20030116
- 主分类号： A61K31/485
- IPC分类号： A61K31/485 ; A61K31/4468 ; A61K31/4535 ; A61K31/454 ; A61K38/07 ; A61M5/142
摘要：
A method of producing analgesia in a mammal is provided by rotational (alternating) intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor agonist, such as a ν-, δ- or λ-opioid receptor agonist for a first period of time, followed by intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor-like receptor 1 (ORL-1) agonist for a second period of time. The intrathecal drug administration of the first and second periods of time may be repeated a plurality of times without attaining tolerance in the mammal to either drug. Implantable apparatus for rotational administration of the active agents is also disclosed.
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