公开(公告)号：EP1406629A1

公开(公告)日：2004-04-14

申请号：EP02721261.2

申请日：2002-02-28

申请人： Omeros Corporation ,  The Regents of The University of California

发明人： DEMOPULOS, Gregory, A. ,  PALMER, Pamela, Pierce

IPC分类号： A61K31/485 ,  A61K31/4468 ,  A61K31/4535 ,  A61K31/454 ,  A61K38/07 ,  A61M5/142

CPC分类号： A61M5/14276 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4468 ,  A61K31/4535 ,  A61K31/485 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  A61M5/16827 ,  A61M5/16877 ,  A61M2202/048 ,  A61M2205/3523

摘要： A method of producing analgesia in a mammal is provided by rotational (alternating) intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor agonist, such as a ν-, δ- or λ-opioid receptor agonist for a first period of time, followed by intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor-like receptor 1 (ORL-1) agonist for a second period of time. The intrathecal drug administration of the first and second periods of time may be repeated a plurality of times without attaining tolerance in the mammal to either drug. Implantable apparatus for rotational administration of the active agents is also disclosed.

公开(公告)号：EP4065165A1

公开(公告)日：2022-10-05

申请号：EP20892727.7

申请日：2020-11-24

申请人： Omeros Corporation

发明人： DEMOPULOS, Gregory, A. ,  DUDLER, Thomas, A.

IPC分类号： A61K39/395 ,  A61P37/06 ,  C07K16/40

公开(公告)号：EP3836965A1

公开(公告)日：2021-06-23

申请号：EP19823617.6

申请日：2019-06-20

申请人： Omeros Corporation

发明人： DEMOPULOS, Gregory, A. ,  DUDLER, Thomas ,  NILSSON, Bo

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/32 ,  C07K16/40

公开(公告)号：EP3525798A1

公开(公告)日：2019-08-21

申请号：EP17861108.3

申请日：2017-10-12

申请人： University Of Leicester ,  Omeros Corporation

发明人： BRUNSKILL, Nigel, John ,  DEMOPULOS, Gregory, A. ,  DUDLER, Tom ,  SCHWAEBLE, Hans-Wilhelm

IPC分类号： A61K31/7105 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P7/00

公开(公告)号：EP2911511A1

公开(公告)日：2015-09-02

申请号：EP13848382.1

申请日：2013-10-23

申请人： Omeros Corporation

发明人： DEMOPULOS, Gregory, A. ,  SHEN, Hui-Rong ,  TEDFORD, Clark, E.

IPC分类号： A01N43/48 ,  A61K31/40

CPC分类号： A61K31/407 ,  A61K9/0048 ,  A61K31/137 ,  A61K31/138 ,  A61K2300/00

摘要： The present invention relates to stable, preservative- and antioxidant-free liquid formulations of phenylephrine and ketorolac for injection.

公开(公告)号：EP2427193A1

公开(公告)日：2012-03-14

申请号：EP10772372.8

申请日：2010-05-03

申请人： Omeros Corporation

发明人： BERGMANN, John, E. ,  CUTSHALL, Neil, S. ,  DEMOPULOS, Gregory, A. ,  FLORIO, Vincent, A. ,  GAITANARIS, George ,  GRAY, Patrick ,  HOHMANN, John ,  ONRUST, Rene ,  ZENG, Hongkui

IPC分类号： A61K31/50 ,  A61K31/415 ,  A61K31/38

CPC分类号： A61K31/551 ,  A61K31/00 ,  A61K31/085 ,  A61K31/122 ,  A61K31/137 ,  A61K31/192 ,  A61K31/195 ,  A61K31/198 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4162 ,  A61K31/425 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/527 ,  A61K31/542 ,  A61K45/06 ,  C07D471/04 ,  A61K2300/00

摘要： A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.

公开(公告)号：EP1434573A2

公开(公告)日：2004-07-07

申请号：EP99970596.5

申请日：1999-10-20

申请人： Omeros Corporation

发明人： DEMOPULOS, Gregory, A. ,  PALMER, Pamela, P. ,  HERZ, Jeffrey, M.

IPC分类号： A61K31/00 ,  A61K31/4406 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/675 ,  A61K31/439 ,  A61K45/06 ,  A61P29/00 ,  A61K31/465

CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/439 ,  A61K31/4406 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/465 ,  A61K31/55 ,  A61K31/675

摘要： A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one neuronal nicotinic acetylcholine receptor agonist and, optionally, additional multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a neuronal nicotinic acetylcholine receptor agonist, a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a ν-opioid agonist.

公开(公告)号：EP1257205A2

公开(公告)日：2002-11-20

申请号：EP01948931.9

申请日：2001-02-07

申请人： Omeros Corporation

发明人： DEMOPULOS, Gregory, A. ,  REED, Scott, W. ,  BACHMAN, Alan, B. ,  KARL, Frederick, T. ,  ALLEN, William, J. ,  ADAMS, Leland, R. ,  THATCHER, G., Lawrence

IPC分类号： A61B17/04

CPC分类号： A61B17/064 ,  A61B17/00491 ,  A61B2017/00004 ,  A61B2017/0646 ,  A61B2017/0647

摘要： A medical fastener (18), preferably bioabsorbable, is used for repairing torn soft tissue, particularly meniscal tissue (16). The fastener (18) can have an enlarged head (22) at the proximate end to engage meniscal tissue (16) adjacent to a tear (14), and a pointed distal tip (21) at the other end to ease insertion of the fastener (18) into the meniscus (16). The shank (20) of the fastener (18) bridges across the tear (14). Opposite ends of the shank (20) are secured in the meniscal tissue (16) by a medical adhesive, preferably bioabsorbable, and preferably at locations remote from the tear (14) so as not to interfere with healing of the tear (14). The fastener (18) can have a blind bore (24) opening through the head (22) of the fastener (18) and extending through the shank (20) to a location close to the tip (21) and generally radial holes (26) communicating between the bore (24) and the exterior of the shank (20). The medical adhesive can be injected through the bore (24) for passage outward through the holes (26).

公开(公告)号：EP4412634A1

公开(公告)日：2024-08-14

申请号：EP22879479.8

申请日：2022-10-06

申请人： Omeros Corporation

发明人： ALI, Mohammed Youssif, Ibrahim ,  DEMOPULOS, Gregory, A. ,  DOULAMI, Christiana ,  SCHWAEBLE, Hans-Wilhelm ,  YABUKI, Munehisa

IPC分类号： A61K38/17 ,  C07K16/40 ,  C07K16/28 ,  A61P35/00 ,  A61P37/00

CPC分类号： A61P37/00 ,  A61P35/00 ,  C07K2319/3320130101 ,  C07K16/2887 ,  C07K2317/9220130101 ,  C07K2317/73420130101 ,  C07K16/2893 ,  C07K16/2896 ,  C07K16/1217 ,  A61K2039/50520130101 ,  C07K16/1275 ,  C07K16/14 ,  C07K16/205 ,  Y02A50/30 ,  C07K14/472 ,  C12N9/6424 ,  C12Y304/21104 ,  C07K2319/0020130101 ,  C07K16/1003

公开(公告)号：EP4275752A3

公开(公告)日：2024-02-21

申请号：EP23191932.5

申请日：2011-11-07

申请人： Omeros Corporation

发明人： DEMOPULOS, Gregory, A. ,  GAITANARIS, George, A.

IPC分类号： A61K31/519 ,  A61P25/30

摘要： This disclosure is directed to treatment of addictions and primary impulse-control disorders using phosphodiesterase 7 (PDE7) inhibitors, alone or in combination with other therapeutic agents.