发明授权
- 专利标题： GLP-1 EXENDIN-4 PEPTIDE ANALOGS AND USES THEREOF
- 专利标题（中）： GLP-1肽类似物毒蜥外泌4及其用途
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申请号： EP02748271.0申请日： 2002-07-30
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公开(公告)号： EP1411968B1公开(公告)日： 2008-09-17
- 发明人: GREIG, Nigel, H. , EGAN, Josephine , DOYLE, Maire , HOLLOWAY, Harold , PERRY, Tracy, Ann
- 申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 申请人地址： The National Institute of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852 US
- 专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： The National Institute of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852 US
- 代理机构： Helbing, Jörg
- 优先权： US309076P 20010731
- 国际公布： WO2003011892 20030213
- 主分类号： A61K38/10
- IPC分类号： A61K38/10 ; A61K38/16 ; C07K7/00 ; C07K14/00 ; C07K14/605 ; A61K38/26
摘要：
The invention relates to novel polypeptide analogues of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or extendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogues thereof for neuroprotective and neurotrophic effects.
公开/授权文献
- EP1411968A2 GLP-1 EXENDIN-4 PEPTIDE ANALOGS AND USES THEREOF 公开/授权日：2004-04-28
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