公开(公告)号：EP1411968B1

公开(公告)日：2008-09-17

申请号：EP02748271.0

申请日：2002-07-30

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： GREIG, Nigel, H. ,  EGAN, Josephine ,  DOYLE, Maire ,  HOLLOWAY, Harold ,  PERRY, Tracy, Ann

IPC分类号： A61K38/10 ,  A61K38/16 ,  C07K7/00 ,  C07K14/00 ,  C07K14/605 ,  A61K38/26

CPC分类号： C07K14/575 ,  A61K38/00 ,  A61K38/2278 ,  A61K38/26 ,  C07K14/57563

摘要： The invention relates to novel polypeptide analogues of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or extendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogues thereof for neuroprotective and neurotrophic effects.

公开(公告)号：EP1411968A2

公开(公告)日：2004-04-28

申请号：EP02748271.0

申请日：2002-07-30

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： GREIG, Nigel, H. ,  EGAN, Josephine ,  DOYLE, Maire ,  HOLLOWAY, Harold ,  PERRY, Tracy, Ann

IPC分类号： A61K38/10 ,  A61K38/16 ,  C07K7/00 ,  C07K14/00

CPC分类号： C07K14/575 ,  A61K38/00 ,  A61K38/2278 ,  A61K38/26 ,  C07K14/57563

摘要： The invention relates to novel polypeptide analogues of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or extendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogues thereof for neuroprotective and neurotrophic effects.

公开(公告)号：EP1105460B1

公开(公告)日：2009-10-07

申请号：EP99942066.4

申请日：1999-08-10

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： EGAN, Josephine ,  PERFETTI, Riccardo ,  PASSANITI, Antonino ,  GREIG, Nigel ,  HOLLOWAY, Harold

IPC分类号： C12N5/06 ,  A61K38/22 ,  A61K38/26 ,  C07K14/605 ,  C07K14/575

CPC分类号： C12N5/0676 ,  A61K35/39 ,  A61K38/00 ,  A61K38/26 ,  C07K14/57563 ,  C12N2501/335

摘要： The present invention relates to a population of insulin producing cells made by a process comprising contacting non-insulin producing cells with a growth factor selected from the group consisting of GLP-1 or Exendin-4, growth factors having amino acid sequences substantially homologous to GLP-1 or Exendin-4, and fragments thereof. The present invention also relates to methods of differentiating non-insulin producing cells into insulin producing cells and of enriching a population of cells for insulin-producing cells. The present invention also relates to methods of treating diabetes.