发明公开
EP1414842A4 ANTISENSE MODULATION OF ACYL COA CHOLESTEROL ACYLTRANSFERASE-2 EXPRESSION
审中-公开
表达酰基CoA的反义调节：胆固醇酰基转移酶-2
- 专利标题： ANTISENSE MODULATION OF ACYL COA CHOLESTEROL ACYLTRANSFERASE-2 EXPRESSION
- 专利标题（中）： 表达酰基CoA的反义调节：胆固醇酰基转移酶-2
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申请号： EP02752413申请日： 2002-07-15
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公开(公告)号： EP1414842A4公开(公告)日： 2005-02-09
- 发明人: CROOKE ROSANNE M , GRAHAM MARK J , LEMONIDIS TARBET KRISTINA M
- 申请人： ISIS PHARMACEUTICALS INC
- 专利权人： ISIS PHARMACEUTICALS INC
- 当前专利权人： ISIS PHARMACEUTICALS INC
- 优先权： US91802601 2001-07-30
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C12N15/113 ; C07H21/04 ; C12N5/00 ; C12Q1/68
摘要：
Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
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