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1.发明公开
公开(公告)号：EP2855500A4
公开(公告)日：2015-12-16
申请号：EP13793955
申请日：2013-05-23
发明人： CROOKE ROSANNE M , GRAHAM MARK J , FREIER SUSAN M
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/34 , C12N2310/341 , C12N2310/346 , C12Y304/21007 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing apo(a) to treat, prevent, ameliorate diseases, disorders or conditions related to apo(a) or Lp(a). Certain diseases, disorders or conditions related to apo(a) or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The antisense compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.
摘要翻译： 本文公开了用于减少apo（a）以治疗，预防或改善与apo（a）或Lp（a）相关的疾病，病症或病症的反义化合物和方法。 与apo（a）或Lp（a）相关的某些疾病，病症或病症包括炎症，心血管和/或代谢疾病，病症或病症。 本文公开的反义化合物可用于治疗有需要的个体中的这些疾病，病症或病症。
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2.发明公开METHOD OF PREPARING OLIGOMERIC COMPOUNDS USING MODIFIED COUPLING PROTOCOLS 审中-公开用于生产低聚的连接，使用改进的偶联方案
公开(公告)号：EP2951191A2
公开(公告)日：2015-12-09
申请号：EP14746224.6
申请日：2014-01-30
IPC分类号： C07H21/02
摘要： Provided herein are methods for the synthesis of oligomeric compounds wherein the standard coupling protocols are modified when coupling bicyclic nucleosides of Formula I. More particularly, the modified coupling protocols provide for a decrease in the ratio of phosphoramidite solution to activator solution in the coupling reagent with an increased contact time. The modified coupling protocols provide for oligomeric compounds having comparable yields to similar oligomeric compounds having modified nucleosides other than bicyclic nucleosides of Formula I.
摘要翻译： 提供在用于worin标准偶联方案被修改当联接的式I更特别地，经改性的耦合协议提供了在亚磷酰胺溶液中的比例，以活化剂溶液与减少在偶联试剂的双环核苷的低聚化合物的合成方法 增加接触时间。 经改性的耦合协议提供了具有可比较的收率以类似的低聚化合物的低聚化合物具有修饰的比式I的双环核苷其他核苷
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3.发明公开METHODS FOR MODULATING METASTASIS-ASSOCIATED-IN-LUNG-ADENOCARCINOMA-TRANSCRIPT-1(MALAT-1) EXPRESSION 有权调制转移的方法与肺腺癌TRANSCRIPT -1-（MALAT-1）表达的连接
公开(公告)号：EP2794880A4
公开(公告)日：2015-10-14
申请号：EP12860563
申请日：2012-12-21
CPC分类号： C12N15/1136 , A61K31/711 , C12N15/113 , C12N2310/11 , C12N2310/113 , C12N2310/315 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/321 , C12N2310/3525
摘要： The present embodiments provide compounds and methods for reducing expression of Metastasis-Associated-in-Lung-Adenocarcinoma-Transcript-1 (MALAT-1) RNA and/or protein in an animal. Such methods are useful for treating cancer, such as colon cancer, intestinal cancer, lung cancer (e.g. non-small cell lung cancer), liver cancer, and/or prostate cancer. In various aspects, the cancer is a primary cancer.
摘要翻译： 本发明实施例提供的化合物和方法用于减少在动物的转移相关功能于肺腺癌转录物-1（马拉特-1）RNA和/或蛋白质的表达。 搜索方法可用于治疗癌症，：如结肠癌，肠癌，肺癌（例如非小细胞肺癌），肝癌，和/或前列腺癌是有用的。 在各种方面中，所述癌症是原发性癌症。
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公开(公告)号：EP2906697A1
公开(公告)日：2015-08-19
申请号：EP13847099.2
申请日：2013-10-15
发明人： BENNETT, C. Frank , FREIER, Susan M. , ROTHSTEIN, Jeffrey D. , DONNELLY, Christopher , SATTLER, Rita, G.
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/111 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12N2310/3521
摘要： Disclosed herein are methods for monitoring expression of C9ORF72 mRNA and protein in an animal with C9ORF72 specific inhibitors. Such C9ORF72 specific inhibitors include antisense compounds.
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公开(公告)号：EP2462153B1
公开(公告)日：2015-07-29
申请号：EP10740495.6
申请日：2010-08-05
发明人： MIGAWA, Michael, T. , SETH, Punit, P. , SWAYZE, Eric, E. , ROSS, Bruce, S. , SONG, Quanlai , HAN, Mingming
IPC分类号： C07H21/00 , A61K31/712
CPC分类号： C12N15/113 , C07H19/06 , C07H19/16 , C07H21/00
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公开(公告)号：EP2176280B2
公开(公告)日：2015-06-24
申请号：EP08781239.2
申请日：2008-07-01
发明人： SWAYZE, Eric, E. , SETH, Punit, P.
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7.发明公开COMPOSITIONS AND METHODS FOR MODULATING TAU EXPRESSION FOR REDUCING SEIZURE AND MODIFYING A NEURODEGENERATIVE SYNDROME 审中-公开组合物和调制DEW表达的方法用于减少神经变性综合征扣押和修改
公开(公告)号：EP2831231A1
公开(公告)日：2015-02-04
申请号：EP13767959.3
申请日：2013-03-14
CPC分类号： C12N15/113 , C07H21/02 , C07H21/04 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are methods for reducing expression of Tau mRNA and protein in an animal with Tau antisense compounds. Also disclosed are methods for modulating splicing of Tau mRNA in an animal with Tau antisense compounds. Such methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof. Examples of neurodegenerative diseases that can be treated, prevented, and ameliorated with the administration Tau antisense oligonucleotides include Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP- 17, Progressive Supranuclear Palsy, Chronic Traumatic Encephalopathy, Epilepsy, and Dravet's Syndrome.
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8.发明授权5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis 有权5,6-二羟基异吲哚衍生物作为接头为低聚物的固相合成
公开(公告)号：EP2708541B1
公开(公告)日：2015-01-28
申请号：EP12199177.2
申请日：2004-11-15
IPC分类号： C07D491/18
CPC分类号： C07D491/18
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公开(公告)号：EP2751269A4
公开(公告)日：2015-01-07
申请号：EP12827475
申请日：2012-08-29
发明人： PRAKASH THAZHA P , SWAYZE ERIC E , COREY DAVID , YU DONGBO
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3341 , C12N2310/341 , C12N2310/343 , C12N2310/344 , C12N2310/351 , C12N2310/3521 , C12N2310/3533 , C12N2310/533 , C12N2320/34
摘要： Described are compounds and methods useful for the treatment and investigation of diseases and disorders associated with expanded repeat-containing RNA molecules.
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公开(公告)号：EP2218727B1
公开(公告)日：2014-12-24
申请号：EP10075221.1
申请日：2004-06-02
CPC分类号： C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
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