发明公开
- 专利标题： IMPROVED HYDROLYTIC KINETIC RESOLUTION OF EPOXIDES
- 专利标题（中）： 改进的水解动力学拆分环氧化物
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申请号： EP02768658.3申请日： 2002-08-22
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公开(公告)号： EP1419128A1公开(公告)日： 2004-05-19
- 发明人: LIU, Yi , DIMARE, Marcello , MARCHESE, Salvatore, A. , JACOBSEN, Eric, N. , JASMIN, Serge
- 申请人： Rhodia Pharma Solution Inc., (formally Rhodia Chirex Inc.)
- 申请人地址： 56 Roland Street Boston, MA 02129 US
- 专利权人： Rhodia Pharma Solution Inc., (formally Rhodia Chirex Inc.)
- 当前专利权人： Rhodia Pharma Solution Inc., (formally Rhodia Chirex Inc.)
- 当前专利权人地址： 56 Roland Street Boston, MA 02129 US
- 代理机构： Kyle, Diana
- 优先权： US314247P 20010822
- 国际公布： WO2003018520 20030306
- 主分类号： C07C27/12
- IPC分类号： C07C27/12 ; C07C27/22 ; C07C29/50 ; C07D301/32 ; C07D303/08
摘要：
The present invention provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. The process includes the step of contacting oxygen and mixture including a racemic chiral epoxy compound, a non-racemic Co(ll) complex catalyst, an aromatic carboxylic acid and water, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound. The present invention also provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. This process includes the step of: contacting a racemic chiral epoxy compound and water in the presence of a non-racemic complex of Co(lll) having an aryl carboxylate counter-anion, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound.
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