公开(公告)号：EP1419128A1

公开(公告)日：2004-05-19

申请号：EP02768658.3

申请日：2002-08-22

申请人： Rhodia Pharma Solution Inc., (formally Rhodia Chirex Inc.)

发明人： LIU, Yi ,  DIMARE, Marcello ,  MARCHESE, Salvatore, A. ,  JACOBSEN, Eric, N. ,  JASMIN, Serge

IPC分类号： C07C27/12 ,  C07C27/22 ,  C07C29/50 ,  C07D301/32 ,  C07D303/08

CPC分类号： C07D303/48 ,  C07B2200/07 ,  C07C27/00 ,  C07C29/106 ,  C07C2523/75 ,  C07D301/32 ,  C07D303/04 ,  C07D303/08 ,  C07C33/26 ,  C07C31/205 ,  C07C31/42

摘要： The present invention provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. The process includes the step of contacting oxygen and mixture including a racemic chiral epoxy compound, a non-racemic Co(ll) complex catalyst, an aromatic carboxylic acid and water, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound. The present invention also provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. This process includes the step of: contacting a racemic chiral epoxy compound and water in the presence of a non-racemic complex of Co(lll) having an aryl carboxylate counter-anion, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound.