发明公开
- 专利标题: MODIFIED RELEASE DOSAGE FORMS
- 专利标题(中): 与改良释放剂型
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申请号: EP02773665.1申请日: 2002-09-28
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公开(公告)号: EP1429737A1公开(公告)日: 2004-06-23
- 发明人: LEE, Der-Yang , LI, Shun-Por , MCTEIGUE, Daniel , PARIKH, Narendra , SOWDEN, Harry, S. , THOMAS, Martin , WYNN, David
- 申请人: McNeil-PPC, INC. , Thomas, Martin
- 申请人地址: Grandview Road Skillman, NJ 08558 US
- 专利权人: McNeil-PPC, INC.,Thomas, Martin
- 当前专利权人: McNeil-PPC, INC.,Thomas, Martin
- 当前专利权人地址: Grandview Road Skillman, NJ 08558 US
- 代理机构: Fisher, Adrian John
- 优先权: US966939 20010928; US966509 20010928; US966497 20010928; US967414 20010928; US966450 20010928
- 国际公布: WO2003026625 20030403
- 主分类号: A61K9/20
- IPC分类号: A61K9/20 ; A61K9/28
摘要:
A dosage form comprises: (a) at least one active ingredient; (b) a core; and(c) a shell which surrounds the core, wherein the shell is substantially free of pores having a diameter of 0.5-5.0 microns, and the shell comprises a first shell portion and a second shell portion which are compositionally different and the dosage form provides a modified release profile of the active ingredient upon contacting of the dosage form with a liquid medium. In another embodiment, the dosage form comprises: (a) at least one active ingredient; (b) a core comprising first and second core portions; and (c) a shell which surrounds the core, wherein the shell comprises first and second shell portions such that the first shell portion resides upon the first core portion and the second shell portion resides upon the second core portion, and at least one of the first or second shell portions or first or second shell portions provides a modified release profile of the active ingredient upon contacting of the dosage form with a liquid medium.
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