发明公开
- 专利标题： REVERSE HYDROXAMIC ACID DERIVATIVES
- 专利标题（中）： REVERSE羟肟酸衍生物
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申请号： EP02767899.4申请日： 2002-09-05
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公开(公告)号： EP1431285A1公开(公告)日： 2004-06-23
- 发明人: SHIMANO, M., C.R.L. KAKEN PHARMACEUTICAL CO., LTD , KAMEI, N., C.R.L. KAKEN PHARMACEUTICAL CO., LTD , TANAKA, T., C.R.L. KAKEN PHARMACEUTICAL CO., LTD , HARADA, T., C.R.L. KAKEN PHARMACEUTICAL CO., LTD , HAINO, M., C.R.L. KAKEN PHARMACEUTICAL CO., LTD , OKUYAMA, A., C.R.L. KAKEN PHARMACEUTICAL CO., LTD , ARAKAWA, Y., C.R.L. KAKEN PHARMACEUTICAL CO., LTD , MURAKAMI, Y., C.R.L. KAKEN PHARMACEUTICAL CO., LTD
- 申请人： Kaken Pharmaceutical Co., Ltd.
- 申请人地址： 28-8, Honkomagome 2-chome, Bunkyo-ku Tokyo 113-8650 JP
- 专利权人： Kaken Pharmaceutical Co., Ltd.
- 当前专利权人： Kaken Pharmaceutical Co., Ltd.
- 当前专利权人地址： 28-8, Honkomagome 2-chome, Bunkyo-ku Tokyo 113-8650 JP
- 代理机构： HOFFMANN EITLE
- 优先权： JP2001272527 20010907
- 国际公布： WO2003022801 20030320
- 主分类号： C07C317/40
- IPC分类号： C07C317/40 ; C07D213/30 ; C07D215/14 ; C07D317/72 ; C07D401/12 ; C07D405/12 ; C07D409/12 ; C07D417/12 ; C07D491/113
摘要：
Reverse hydroxamic acid derivatives having specific structure represented by a general formula (Ia):
(wherein A is a hydrogen atom or the like; Ar 1 is an arylene or the like; Ar 2 is an optionally substituted aryl, a heteroaryl or the like; R 1 is a hydrogen atom, an alkyl or the like; R 2a is a substituted cycloaryl, a heterocycloaryl or the like) and a general formula (I):
(wherein A, Ar 1 , Ar 2 , and R 1 are the same as defined above and R 2 is an hydrogen atom, R 2a or the like) and salts thereof, which have TNF-α converting enzyme (TACE) inhibitory activity.
(wherein A is a hydrogen atom or the like; Ar 1 is an arylene or the like; Ar 2 is an optionally substituted aryl, a heteroaryl or the like; R 1 is a hydrogen atom, an alkyl or the like; R 2a is a substituted cycloaryl, a heterocycloaryl or the like) and a general formula (I):
(wherein A, Ar 1 , Ar 2 , and R 1 are the same as defined above and R 2 is an hydrogen atom, R 2a or the like) and salts thereof, which have TNF-α converting enzyme (TACE) inhibitory activity.
公开/授权文献
- EP1431285B1 REVERSE HYDROXAMIC ACID DERIVATIVES 公开/授权日：2009-01-07
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