- 专利标题： METHOD FOR THE AMPLIFICATION OF A POXVIRUS UNDER SERUM FREE CONDITIONS
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申请号： EP03766057.8申请日： 2003-09-01
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公开(公告)号： EP1434858B2公开(公告)日： 2018-12-19
- 发明人: RÄTHE, INGMAR , Felder, Eva , HELLER, Karl
- 申请人： Bavarian Nordic A/S
- 申请人地址： Boegeskovvej 9 3490 Kvistgaard DK
- 专利权人： Bavarian Nordic A/S
- 当前专利权人： Bavarian Nordic A/S
- 当前专利权人地址： Boegeskovvej 9 3490 Kvistgaard DK
- 代理机构： Vossius & Partner Patentanwälte Rechtsanwälte mbB
- 优先权： DK200201302 20020905
- 国际公布： WO2004022729 20040318
- 主分类号： C12N5/0735
- IPC分类号： C12N5/0735 ; C12N5/077 ; C12N7/00 ; A61K39/12 ; A61P31/12
摘要：
The present invention relates to a method for the cultivation of primary cells. The primary cells are cultivated in a serum free medium comprising a factor selected from the group consisting of growth factors and attachment factors. The method for the cultivation of primary cells may be one step in a method for the amplification of viruses, such as poxviruses. According to this latter method the primary cells are cultivated in a serum free medium comprising a factor selected from the group consisting of growth factors and attachment factors. The cells are then infected with the virus and the infected cells are cultivated in serum free medium until progeny virus is produced.
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