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1.发明公开
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2.发明授权
公开(公告)号：EP2879702B9
公开(公告)日：2020-02-26
申请号：EP13717721.8
申请日：2013-03-15
申请人： Bavarian Nordic A/S
IPC分类号： A61K39/155 , C12Q1/68
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公开(公告)号：EP3188753B1
公开(公告)日：2019-12-18
申请号：EP15767631.3
申请日：2015-09-03
申请人： Bavarian Nordic A/S , Janssen Vaccines & Prevention B.V. , The United States of America, as represented by The Secretary, Department of Health and Human Services
发明人： VOLKMANN, Ariane , STEIGERWALD, Robin , DIRMEIER, Ulrike , PAU, Maria Grazia , CALLENDRET, Benoit Christophe Stephan , WARD, Lucy A.
IPC分类号： A61K39/12
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公开(公告)号：EP2367944B1
公开(公告)日：2019-01-09
申请号：EP09764186.4
申请日：2009-11-27
申请人： Bavarian Nordic A/S
IPC分类号： C12N15/863 , A61K39/285
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公开(公告)号：EP1434858B2
公开(公告)日：2018-12-19
申请号：EP03766057.8
申请日：2003-09-01
申请人： Bavarian Nordic A/S
发明人： RÄTHE, INGMAR , Felder, Eva , HELLER, Karl
IPC分类号： C12N5/0735 , C12N5/077 , C12N7/00 , A61K39/12 , A61P31/12
CPC分类号： C12N7/08 , C12N5/0606 , C12N5/0652 , C12N7/00 , C12N2500/24 , C12N2501/11 , C12N2510/02 , C12N2710/24151
摘要： The present invention relates to a method for the cultivation of primary cells. The primary cells are cultivated in a serum free medium comprising a factor selected from the group consisting of growth factors and attachment factors. The method for the cultivation of primary cells may be one step in a method for the amplification of viruses, such as poxviruses. According to this latter method the primary cells are cultivated in a serum free medium comprising a factor selected from the group consisting of growth factors and attachment factors. The cells are then infected with the virus and the infected cells are cultivated in serum free medium until progeny virus is produced.
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公开(公告)号：EP3188754A1
公开(公告)日：2017-07-12
申请号：EP15771771.1
申请日：2015-09-03
申请人： Bavarian Nordic A/S , Janssen Vaccines & Prevention B.V. , The United States of America, as represented by The Secretary, Department of Health and Human Services
发明人： VOLKMANN, Ariane , STEIGERWALD, Robin , DIRMEIER, Ulrike , CALLENDRET, Benoit Christophe Stephan , DOUOGUIH, Macaya Julie , WARD, Lucy A.
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5256 , A61K2039/545 , C12N2710/10343 , C12N2710/24043 , C12N2760/14134 , C12N2760/14171 , C12N2760/14234
摘要： Compositions and methods are described for generating an improved effective immune response against an immunogen in humans. The enhanced immune response, is obtained by using an MVA vector as a prime and an adenovirus vector as a boost and is characterized by a high level of antibody response specific to the immunogen, and an enhanced cellular immune response. The compositions and methods can be used to provide a protective immunity against a disease, such as an infection of one or more subtypes of Ebola and Marburg filoviruses, in humans.
摘要翻译： 描述了组合物和方法用于产生抗人免疫原的改善的有效免疫应答。 通过使用MVA载体作为主要载体和腺病毒载体作为加强剂获得增强的免疫应答，其特征在于对免疫原特异性的高水平抗体应答和增强的细胞免疫应答。 该组合物和方法可用于提供针对人的疾病的保护性免疫，例如埃博拉病毒和马尔堡病毒的一种或多种亚型的感染。
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7.发明授权USE OF A MODIFIED PROXVIRUS FOR THE RAPID INDUCTION OF IMMUNITY AGAINST A POXVIRUS OR OTHER INFECTIOUS AGENTS 有权一种改进的天花病毒针对天花病毒或者其他感染免疫功能的快速感应USE
公开(公告)号：EP1855720B1
公开(公告)日：2016-10-05
申请号：EP06707039.1
申请日：2006-02-17
申请人： Bavarian Nordic A/S
发明人： MATEO, Luis , CHAPLIN, Paul
IPC分类号： A61K39/285 , A61K39/145 , A61K39/29 , A61K39/12 , A61P37/04
CPC分类号： A61K39/285 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , C12N15/86 , C12N2710/24143
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8.发明公开POXVIRAL VECTORS FOR LOW ANTIBODY RESPONSE AFTER A FIRST PRIMING IMMUNIZATION 审中-公开POXVIRUS-VEKTORENFÜRNIEDRIGE防盗报警器NACH EINER ERSTEN GRUNDIMMUNISIERUNG
公开(公告)号：EP2864487A1
公开(公告)日：2015-04-29
申请号：EP13730812.8
申请日：2013-06-21
申请人： Bavarian Nordic A/S
IPC分类号： C12N15/86
CPC分类号： A61K39/285 , A61K2039/53 , C12N7/00 , C12N15/11 , C12N15/86 , C12N2710/24122 , C12N2710/24134 , C12N2710/24143 , C12N2830/60
摘要： The invention is drawn to compositions and methods for the induction of an immune response, in particular a strong CD8 T cell response, to a specific antigenic determinant without raising a significant antibody response to the antigenic determinant after a first, priming immunization. The method comprises administering to the host a recombinant poxviral vector comprising a transcriptional control element comprising an early and/or late element linked to a nucleotide sequence encoding the antigenic determinant. The recombinant poxviral vector comprises a transcriptional control element comprising an early and/or late element linked to a nucleotide sequence encoding the antigenic determinant. The late element may be stronger than the cowpox ATI promoter in HeLa cells.
摘要翻译： 本发明涉及用于诱导特异性抗原决定簇的免疫应答特别是强CD8T细胞应答的组合物和方法，而不会在第一次启动免疫后对抗原决定簇产生显着的抗体应答。 该方法包括向宿主施用包含转录控制元件的重组痘病毒载体，其包含与编码抗原决定簇的核苷酸序列连接的早期和/或晚期元件。 重组痘病毒载体包含转录控制元件，其包含与编码抗原决定簇的核苷酸序列连接的早期和/或晚期元件。 晚期元件可能比HeLa细胞中的牛痘ATI启动子更强。
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9.发明公开OPTIMIZED EARLY-LATE PROMOTER COMBINED WITH REPEATED VACCINATION FAVORS CYTOTOXIC T CELL RESPONSE AGAINST ANTIGENS IN REPLICATION DEFICIENT RECOMBINANT VIRUS VACCINES 审中-公开WITH THE细胞毒性T细胞应答抗原反复接种受益人COMBINED IMPROVED EARLY晚期启动子的疫苗病毒的复制缺陷型重组
公开(公告)号：EP2405939A1
公开(公告)日：2012-01-18
申请号：EP10708732.2
申请日：2010-03-11
申请人： Bavarian Nordic A/S
发明人： BRINKMANN, Kay , BAUR, Karen , HAUSMANN, Jürgen
IPC分类号： A61K39/285 , C07K14/07 , C12N15/863
CPC分类号： A61K39/285 , A61K39/12 , C07K14/005 , C12N15/86 , C12N2710/24122 , C12N2710/24143 , C12N2830/60
摘要： The invention is drawn to compositions and methods for the induction of a strong CD8 T cell response to a specific antigen(s). The combination of an early/late hybrid promoter directing strongly enhanced early expression of a neoantigen with at least three immunization rounds resulted in a highly efficient neoantigen-specific CD8 T cell response. This combination reversed the immunodominance hierarchy and converted a moderately immunogenic and subdominant CD8 T cell epitope into the immunodominant epitope.
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10.发明公开Monoparamunitätsinducer basierend auf attenuierten Myxomaviren des Kaninchens 审中-公开基于减毒兔粘液瘤病毒的单细胞免疫诱导物
公开(公告)号：EP2327420A2
公开(公告)日：2011-06-01
申请号：EP10014101.9
申请日：2005-01-21
申请人： Bavarian Nordic A/S
发明人： Mayr, Anton , Mayr, Barbara
IPC分类号： A61K39/275 , A61K35/76 , C12N7/06 , C12N7/08
CPC分类号： A61K39/275 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , C12N2710/24032
摘要： Die vorliegende Erfindung betrifft Monoparamunitätsinducer auf der Basis von paramunisierenden Viren oder Viruskomponenten eines Myxomavirus-Stammes von typisch generalisierend erkrankten Kaninchen, ein Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel zur regulativen Optimierung der paramunisierenden Aktivitäten für die Prophylaxe und Therapie von diversen Dysfunktionen bei Mensch und Tier.
摘要翻译： 本发明涉及基于副免疫病毒或典型广义患病兔，它们的制备以及它们作为药物用于在人类中预防和各种病症的治疗中的副免疫活动的调节优化的使用和处理的粘液瘤病毒株的病毒组分monoparamunity 动物。
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