发明授权
- 专利标题： NEW POTENT, SELECTIVE AND NON TOXIC C-KIT INHIBITORS
- 专利标题（中）： C-KIT抑制剂
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申请号： EP02755511.9申请日： 2002-06-28
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公开(公告)号： EP1434991B1公开(公告)日： 2007-10-17
- 发明人: MOUSSY, Alain , DUBREUIL, Patrice , HERMINE, Olivier
- 申请人： AB Science , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE RENE DESCARTES, (PARIS V) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
- 申请人地址： 3, avenue George V 75008 Paris FR
- 专利权人： AB Science,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),UNIVERSITE RENE DESCARTES, (PARIS V),CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS),ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
- 当前专利权人： AB Science,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),UNIVERSITE RENE DESCARTES, (PARIS V),CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS),ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
- 当前专利权人地址： 3, avenue George V 75008 Paris FR
- 代理机构： Warcoin, Jacques
- 优先权： US301404P 20010629
- 国际公布： WO2003003006 20030109
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; G01N33/566
摘要：
The present invention relates to a screening method allowing the identification and selection of compounds targeting the transphosphorylase (also called phosphotransferase) domain of c-kit, more particularly compounds selected to be potent inhibitors of constitutively activated c-kit, while being unable to inhibit other activation pathways such as for example the pathways leading to death of IL-3 dependent cells cultured in presence of IL-3.
公开/授权文献
- EP1434991A2 NEW POTENT, SELECTIVE AND NON TOXIC C-KIT INHIBITORS 公开/授权日：2004-07-07
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