发明公开
- 专利标题: METALLOTHIONEINE-CONTAINING LIPOSOMES
- 专利标题(中): 含有金属硫蛋白脂质体
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申请号: EP02777670.7申请日: 2002-10-24
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公开(公告)号: EP1439822A1公开(公告)日: 2004-07-28
- 发明人: HIDALGO PAREJA, Juan , GONZALEZ DUARTE, Pilar , GONZALEZ ENSENAT, PedroTranstechnics, S.L. , PENKOWA, MilenaUniversity of Copenhagen
- 申请人: UNIVERSITAT AUTONOMA DE BARCELONA , University of Copenhagen , TRANSTECHNICS, S.L.
- 申请人地址: 08193 Bellaterra ES
- 专利权人: UNIVERSITAT AUTONOMA DE BARCELONA,University of Copenhagen,TRANSTECHNICS, S.L.
- 当前专利权人: UNIVERSITAT AUTONOMA DE BARCELONA,University of Copenhagen,TRANSTECHNICS, S.L.
- 当前专利权人地址: 08193 Bellaterra ES
- 代理机构: Ponti Sales, Adelaida
- 优先权: ES200102435 20011026
- 国际公布: WO2003035033 20030501
- 主分类号: A61K9/127
- IPC分类号: A61K9/127 ; A61K38/17 ; A61P25/28
摘要:
The composition comprises a dispersion of nanocorpuscles in an aqueous solution as a dispersant and a pharmaceutically acceptable alcohol as co-dispersant or cosolvent, said nanocorpuscles having at least one lipid bilayer comprising at least one biliar salt, e.g. sodium cholate, and at least one phospholipid, e.g. soy lecitine; these nanocorpuscles having an average diameter lower than 500 nm; and including metallothioneine in their interior. The process for obtaining the particles comprises: a) prepare an aqueous solution of at least one biliar salt and metallothioneine; b) prepare an alcoholic solution of the phospholipid; c) jointly homogenise both solutions. This pharmaceutical composition can be used as a medicament, particularly in the treatment of neurodegenerative and neurological disorders, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, etc.
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