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公开(公告)号：EP2394667A1
公开(公告)日：2011-12-14
申请号：EP10382169.0
申请日：2010-06-10
IPC分类号： A61K48/00 , C12N15/68 , C12N15/864 , C12N15/67 , C12N9/16
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0066 , C12N9/14 , C12N15/52 , C12N15/8645 , C12N2750/14143 , C12N2830/008 , C12N2830/48 , C12N2840/105
摘要： The present invention provides new sequences, gene constructions, vectors and pharmaceutical compositions for the treatment of diseases and specially, for the treatment of mucopolysaccharidoses.
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2.发明公开METALLIZATION PROCESS TO OBTAIN A MICROELECTRODE ON A PHOTOPATTERNABLE SUBSTRATE AND ITS BIOMEDICAL APPLICATION ON AN ORGAN TRANSPLANT MONITORING DEVICE 有权金属化用于生产中的微量铅对可光成像的承印物及其在器官移植MONITOR医学领域的应用
公开(公告)号：EP2296541A1
公开(公告)日：2011-03-23
申请号：EP09707308.4
申请日：2009-02-04
申请人： Ikerlan, S. Coop , Universitat Autonoma de Barcelona , Consejo Superior De Investigaciones Científicas , I2M-Design , Sociedad española de carburos metalicos, S.A.
发明人： BLANCO BARRO, Francisco Javier , TIJERO SERNA, Maria , FERNANDEZ LEDESMA, Luis Jose , AGUILO LLOBET, Jordi , VILLA SANZ, Rosa , CALDERON, Enric , GOMEZ SUAREZ, Cristina , GABRIEL BUGUÑA, Gemma
CPC分类号： A61B5/04001 , A61B5/413 , A61B2562/028 , A61B2562/125
摘要： Metallization process to obtain a microelectrode on a photopatternable polymeric substrate comprising the steps of depositing a material withlow adhesion, spin coating a negative photoresin A, Patterning its design,, protecting its uncured areas, depositing apositive photoresin B, and etch awaythem, Patterning the electrode using photolithography, metallizing the resulting surface, Etching away the positive photoresin polymers B and B', spin-coating a negative photoresin A and finally performing the final development, hence overcoming the state of the art difficulties providing a process for obtaining a photopatterned polymeric substrate microelectrode, with the ductility required to prevent the microelectrode from breaking and the thickness required to avoid folding during the insertion.
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3.发明公开METHOD AND KIT FOR THE GENOTYPIFICATION OF HLA-B27 BASED ON REAL TIME PCR 审中-公开HLA-B27的方法和试剂盒基因分型实时PCR的
公开(公告)号：EP1741791A9
公开(公告)日：2009-07-29
申请号：EP04805142.9
申请日：2004-12-03
发明人： JUAN OTERO, Manuel, LIRAD-SSR-CTBT , CASAMITJANA PONCES, Natàlia, LIRAD-SSR-CTBT , PUJOL BORRELL, Ricardo, LIRAD-SSR-CTBT , COLOBRAN ORIOL, Roger, LIRAD-SSR-CTBT , PALOU RIVERA, Eduardo, LIRAD-SSR-CTBT , FANER CANET, Maria Rosa, LIRAD-SSR-CTBT , RIBERA CRUSAFONT, Ana, LIRAD-SSR-CTBT
IPC分类号： C12Q1/68
CPC分类号： C07K14/70539 , C12Q1/6883 , C12Q2600/156
摘要： The invention relates to a method for determining alleles of the 27 allelic group of B locus of human leukocyte antigen (HLA-B27) from a nucleic acid sample and to a kit for performing this method. The kit comprises allele-specific primers for using in real-time polymerase chain reaction (PCR), and allele-specific fluorescently labelled probes or an intercalating agent, for detecting fluorescence signals. The analysis is completed with the determination of the melting temperatures of the amplified nucleic acid sequences. It overcomes some of the limitations of conventional DNA-based typing methods, in terms of time, possibility of automation, and increase in resolution, while reducing the number of PCR reactions. It is useful e.g. for determining susceptibility for a specific disease.
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公开(公告)号：EP1754452A1
公开(公告)日：2007-02-21
申请号：EP05701669.3
申请日：2005-01-13
IPC分类号： A61D1/00
CPC分类号： A61B17/8061
摘要： The invention relates to a canine carpal arthrodesis plate consisting of a long metal element comprising two arms, namely a proximal arm and a distal arm, as well as holes for the insertion of fixing screws and a central hole, the aforementioned arms being separated by an intermediate spacing at the plate application face. According to the invention, the distal arm forms a small inclination angle in relation to the proximal arm.
摘要翻译： 本发明涉及一种犬齿腕关节固定板，其由包括两个臂即近端臂和远端臂的长金属元件以及用于插入固定螺钉和中心孔的孔构成，前述臂由 在板材应用面的中间间距。 根据本发明，远端臂相对于近端臂形成小倾角。
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5.发明公开METHOD AND KIT FOR THE GENOTYPIFICATION OF HLA-B27 BASED ON REAL TIME PCR 审中-公开VERFAHREN UND KIT ZUR GENOTYPISIERUNG VON HLA-B27 AUF ECHTZEIT-PCR-BASIS
公开(公告)号：EP1741791A2
公开(公告)日：2007-01-10
申请号：EP04805142.9
申请日：2004-12-03
发明人： JUAN OTERO, Manuel, LIRAD-SSR-CTBT , CASAMITJANA PONCES, Natàlia, LIRAD-SSR-CTBT , PUJOL BORRELL, Ricardo, LIRAD-SSR-CTBT , COLOBRAN ORIOL, Roger, LIRAD-SSR-CTBT , PALOU RIVERA, Eduardo, LIRAD-SSR-CTBT , FANER CANET, Maria Rosa, LIRAD-SSR-CTBT , RIBERA CRUSAFONT, Ana, LIRAD-SSR-CTBT
IPC分类号： C12Q1/68
CPC分类号： C07K14/70539 , C12Q1/6883 , C12Q2600/156
摘要： The invention relates to a method for determining alleles of the 27 allelic group of B locus of human leukocyte antigen (HLA-B27) from a nucleic acid sample and to a kit for performing this method. The kit comprises allele-specific primers for using in real-time polymerase chain reaction (PCR), and allele-specific fluorescently labelled probes or an intercalating agent, for detecting fluorescence signals. The analysis is completed with the determination of the melting temperatures of the amplified nucleic acid sequences. It overcomes some of the limitations of conventional DNA-based typing methods, in terms of time, possibility of automation, and increase in resolution, while reducing the number of PCR reactions. It is useful e.g. for determining susceptibility for a specific disease.
摘要翻译： 本发明涉及一种用于确定来自核酸样品的人类白细胞抗原（HLA-B27）的B基因座的等位基因的等位基因和用于进行该方法的试剂盒的方法。 该试剂盒包括用于实时聚合酶链反应（PCR）的等位基因特异性引物和用于检测荧光信号的等位基因特异性荧光标记探针或插入剂。 通过确定扩增的核酸序列的解链温度来完成分析。 克服了传统的基于DNA的打字方法的一些局限性，从时间，自动化的可能性和分辨率的提高，同时减少了PCR反应的数量。 这是有用的 用于确定特定疾病的易感性。
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6.发明公开MODULAR SYSTEM COMPRISING MULTIPLE AUTOMATED MINI-BIOREACTORS FOR HIGH-THROUGHPUT SCREENING (HTS) IN BIOTECHNOLOGY 有权多重自动MINI-生物反应器综合模块化系统在生物技术与（HTS）高通量筛选
公开(公告)号：EP1580261A1
公开(公告)日：2005-09-28
申请号：EP03811786.7
申请日：2003-11-27
发明人： BRAG S BARDIA, Ramon , ROSSELL FERRER, Xavier , RIU COSTA, Pere, Joan , G DIA CASABLANCAS, Francesc , CAIR BADILLO, Jordi, Joan , PAREDES MUNOZ, Carles , RODR GUEZ OMEDES, Ferran
摘要： The invention relates to a method and a device which are used to obtain and maintain multiple biological cultures, with environmental parameters similar to those of large bioreactors /from 1L) and with a degree of measurement automation similar to that currently obtained using at least the following: measurement and control of temperature, agitation and aeration, measurement and control of pH and dissolved oxygen and measurement of the biomass
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7.发明公开Metallization process to obtain a microelectrode on a photopatternable substrate and its biomedical application on an organ transplant monitoring device 审中-公开用于获得可光图案化基板上的装置的微电极和其生物医学应用器官移植的监测金属化工艺
公开(公告)号：EP2087838A1
公开(公告)日：2009-08-12
申请号：EP08380028.4
申请日：2008-02-05
申请人： Ikerlan, S. Coop. , Universitat Autonoma de Barcelona , Consejo Superior de Investigaciones Cientificas , I2M-Design , Sociedad española de carburos metalicos, S.A.
发明人： Blanco Barro, Francisco Javier , Tijero Serna, Maria , Fernandez Ledesma, Luis Jose , Aguilo Llobet, Jordi , Villa Sanz, Rosa , Calderon, Enric , Gomez Suarez, Cristina , Gabriel Buguña, Gemma
CPC分类号： A61B5/04001 , A61B5/413 , A61B2562/028 , A61B2562/125
摘要： Metallization process to obtain a microelectrode on a photopatternable polymeric substrate comprising the steps of depositing a material with low adhesion, spin coating a negative photoresin A, Patterning its design, protecting its uncured areas, depositing a positive photoresin B, and etch away them, Patterning the electrode using photolithography, metallizing the resulting surface, Etching away the positive photoresin polymers B and B', spin-coating a negative photoresin A and finally performing the final development, hence overcoming the state of the art difficulties providing a process for obtaining a photopatterned polymeric substrate microelectrode, with the ductility required to prevent the microelectrode from breaking and the thickness required to avoid folding during the insertion.
摘要翻译： 金属化工艺，以获得在照片图案的微电极能够聚合物基材包括沉积具有低粘附力的材料，旋涂负感光树脂A，图案化的设计，保护其未固化的区域，沉积正性光树脂B的步骤，和蚀刻awaythem，图案化 使用光刻法，金属化所得表面，蚀刻掉正感光树脂聚合物B和B”的电极中，旋涂负感光树脂A和最后进行的最终发展，因此克服了用于获得photopatterned提供处理的技术困难的状态 聚合物基底的微电极，与所要求的延展性，以防止破坏微电极，并避免在插入期间折叠所需要的厚度。
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公开(公告)号：EP1439822A1
公开(公告)日：2004-07-28
申请号：EP02777670.7
申请日：2002-10-24
发明人： HIDALGO PAREJA, Juan , GONZALEZ DUARTE, Pilar , GONZALEZ ENSENAT, PedroTranstechnics, S.L. , PENKOWA, MilenaUniversity of Copenhagen
摘要： The composition comprises a dispersion of nanocorpuscles in an aqueous solution as a dispersant and a pharmaceutically acceptable alcohol as co-dispersant or cosolvent, said nanocorpuscles having at least one lipid bilayer comprising at least one biliar salt, e.g. sodium cholate, and at least one phospholipid, e.g. soy lecitine; these nanocorpuscles having an average diameter lower than 500 nm; and including metallothioneine in their interior. The process for obtaining the particles comprises: a) prepare an aqueous solution of at least one biliar salt and metallothioneine; b) prepare an alcoholic solution of the phospholipid; c) jointly homogenise both solutions. This pharmaceutical composition can be used as a medicament, particularly in the treatment of neurodegenerative and neurological disorders, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, etc.
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9.发明公开LIQUID PRODUCT OF VEGETABLE ORIGIN AS MILK SUBSTITUTE 审中-公开FLUESSIGPRODUKT MIT PFLANZLICHEM URSPRUNG ALS MILCHERSATZ
公开(公告)号：EP1338206A1
公开(公告)日：2003-08-27
申请号：EP01998232.1
申请日：2001-11-29
发明人： GUAMIS LOPEZ, Buenaventura , QUEVEDO TERRI, Joan Miquel , TRUJILLO MESA, Antonio Jose , FELIPE CUYAS, Xavier
CPC分类号： C12Y302/01001 , A23C11/103 , A23L2/52 , A23L2/84 , A23L7/107 , A23L25/30 , A23L33/105
摘要： Relates to a liquid product of plant origin that can be used as an alternative to liquid milk of animal origin. It is characterised in that it contains essentially an extract of tiger nut, an extract of quinoa and a mixture of enzymes of the α-amylase type. Said mixture includes α-amylases of different optimum temperatures of hydrolysis of starch in order to avoid jellification of the starch in preservation heat treatments, while at the same time providing maltodextrins and glucose.
摘要翻译： 涉及植物来源的液体产品，可用作动物来源的液体牛奶的替代品。 其特征在于其基本上含有虎皮提取物，藜麦提取物和α-淀粉酶类型的混合物。 所述混合物包括淀粉水解不同最佳温度的α-淀粉酶，以避免在保鲜热处理中淀粉的凝胶化，同时提供麦芽糖糊精和葡萄糖。
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10.发明公开Methods and systems for providing oxygen to a patient 审中-公开Verfahren und Systeme zur Bereitstellung von Sauerstofffüreinen Patienten
公开(公告)号：EP2893948A1
公开(公告)日：2015-07-15
申请号：EP14382007.4
申请日：2014-01-10
申请人： Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) , UNIVERSITAT AUTONOMA DE BARCELONA , Centro de Investigación Biomédica en Red (CIBER)
CPC分类号： A61M16/0677 , A61M16/0051 , A61M16/026 , A61M2202/0208 , A61M2205/3569 , A61M2205/3592 , A61M2230/205 , A61M2230/50 , A61M2230/63 , A61M2230/65
摘要： System for providing oxygen to a patient, comprising a sensing device (41) having an oxygen sensor (41) for obtaining one or more measurements of a level of oxygen in patient's blood, an oxygen provider (45) for providing oxygen to the patient, and a control unit (40). The control unit (40) is configured to receive the level of oxygen in blood from the oxygen sensor (41), and to determine a parameter representative of oxygen insufficiency by comparing the level of oxygen in blood with an oxygen level threshold. The control unit (40) is further configured to determine an oxygen need depending at least on the parameter representative of oxygen insufficiency, and to cause the oxygen provider (45) to continuously provide the oxygen need to the patient until the oxygen need is determined to be substantially null.
摘要翻译： 用于向患者提供氧气的系统，包括具有氧传感器（41）的感测装置（41），用于获得患者血液中氧气水平的一个或多个测量值，用于向患者提供氧气的氧供应器（45） 和控制单元（40）。 控制单元（40）被配置为从氧传感器（41）接收血液中的氧含量，并且通过将血液中的氧水平与氧水平阈值进行比较来确定代表氧气不足的参数。 控制单元（40）还被配置为至少根据代表氧气不足的参数来确定氧气需求，并且使得氧供应者（45）连续地向患者提供氧气需求，直到氧需求被确定为 基本上是空的
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