5-Amidino-2-hydroxybenzenesulfonamide derivatives represented by the following general formula [I] exhibiting a potent and selective inhibitory activity on activated blood coagulation factor X and thus being useful as preventives or remedies for diseases in the onset of which activated blood coagulation factor X participates: [I] wherein R1 represents optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted alkenyl, cycloalkyl, lower acyl, etc.; Q represents hydrogen or optionally substituted lower alkyl; and Z represents hydrogen, hydroxy, etc.; pharmacologically acceptable salts thereof, medicinal compositions containing the same and intermediates in the production thereof. These compounds are useful as preventives or remedies for various diseases such as brain infarction, cerebral thrombosis, cerebral embolism, TIA, cerebral vascular jerk, Alzheimer’s diseases, myocardial infarction, heart attack, heart failure, thrombosis, pulmonary infarction and pulmonary embolism.