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    PHENYLETHANOLAMINOTETRALINCARBOXAMIDE DERIVATIVES
    1.
    发明公开
    PHENYLETHANOLAMINOTETRALINCARBOXAMIDE DERIVATIVES 失效
    PHENYLETHANOLAMINOTETRALINCARBOXAMID衍

    公开(公告)号：EP0893432A4

    公开(公告)日：2002-01-02

    申请号：EP97914598

    申请日：1997-04-04

    申请人： KISSEI PHARMACEUTICAL

    发明人： KITAZAWA MAKIO ,  OKAZAKI KOSUKE ,  TAMAI TETSURO ,  SAITO MASARU ,  TANAKA NOBUYUKI ,  KOBAYASHI HIROAKI ,  KIKUCHI KEN ,  MURANAKA HIDEYUKI

    IPC分类号： A61K31/165 ,  A61K31/445 ,  A61K31/535 ,  C07C235/06 ,  C07D295/16 ,  C07D295/185 ,  A61K31/495 ,  C07D295/18

    CPC分类号： C07D295/185 ,  C07C235/06 ,  C07C2602/10

    摘要： Phenylethanolaminotetralincarboxamide derivative represented by general formula (I) and pharmacologically acceptable salts thereof, wherein A represents lower alkylene; B represents amino, di(lower alkyl)amino or 3- to 7-membered alicyclic amino which may bear oxygen on the ring; the asterisked carbon atom represents a carbon atom with an R- or S-configuration or a mixture of such atoms; and the carbon atom labeled with (S) represents a carbon atom with an S-configuration. These compounds have selective β2-adrenergic receptor stimulating effects while reducing the burden on the heart, such as tachycardia, and are useful as preventives for threatened abortion and premature birth, bronchodilator, and agents for remission and lithagogue for urinary calculus.

    摘要翻译： 由通式（I）表示的苯乙醇氨基四氢吡喃甲酰胺衍生物及其药理学上可接受的盐，其中A代表低级亚烷基; B表示氨基，二（低级烷基）氨基或在环上可以带有氧的3-7元脂环族氨基; 带星号的碳原子表示具有R-或S-构型的碳原子或这些原子的混合物; 并且用（S）标记的碳原子表示具有S-构型的碳原子。 这些化合物具有选择性β2 - 肾上腺素能受体刺激作用，同时减轻心脏负担，例如心动过速，并且可用作预先堕胎和早产的预防剂，支气管扩张剂和用于缓解泌尿系结石的药物。

    3,4-DISUBSTITUTED PHENYLETHANOLAMINOTETRALINCARBOXAMIDE DERIVATIVES
    7.
    发明公开
    3,4-DISUBSTITUTED PHENYLETHANOLAMINOTETRALINCARBOXAMIDE DERIVATIVES 失效
    3,4-二异丙基苯甲酰胺氧基 - 羧甲酰胺衍生物

    公开(公告)号：EP0882704A4

    公开(公告)日：2000-06-14

    申请号：EP97902714

    申请日：1997-02-18

    申请人： KISSEI PHARMACEUTICAL

    发明人： KITAZAWA MAKIO ,  OKAZAKI KOSUKE ,  TAMAI TETSURO ,  SAITO MASARU ,  TANAKA NOBUYUKI ,  KOBAYASHI HIROAKI ,  KIKUCHI KEN ,  MURANAKA HIDEYUKI

    IPC分类号： C07C235/06 ,  C07D295/185 ,  A61K31/165 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  C07D295/18

    CPC分类号： C07D295/185 ,  C07C235/06 ,  C07C2602/10

    摘要： 3,4-Disubstituted phenylethanolaminotetralincarboxamide derivatives represented by general formula (I) and their pharmacologically acceptable salts having a selective β2-adrenergic receptor stimulating effect with a relieved burden on the heart such as frequent pulse. In said formula, A represents lower alkylene; B represents amino, di(lower alkyl)amino or 3- to 7-membered alicyclic amino optionally containing oxygen in the ring; n is an integer of 1 or 2; the carbon atom marked with '*' means a carbon atom or the R- or S- configuration or a mixture thereof; and the carbon atom marked with '(S)' means a carbon atom of the S-configuration. These compounds are useful as a preventive for threatened abortion/premature birth, a bronchodilator and a pain-relieving and lithagogue agent in ureterolithiasis.

    摘要翻译： 由通式（1）表示的3,4-二取代苯乙醇氨基四氢化萘甲酰胺衍生物及其具有选择性β2-肾上腺素能受体刺激作用的药理学上可接受的盐，其具有缓解的心脏负担，例如频繁脉冲。 在所述式中，A表示低级亚烷基; B代表环中任选含有氧的氨基，二（低级烷基）氨基或3-至7-元脂环族氨基; n为1或2的整数; 标有“*”的碳原子是指碳原子或R-或S-构型或其混合物; 标有“（S）”的碳原子是指S-构型的碳原子。 这些化合物可用作威胁性流产/早产的预防剂，支气管扩张剂和输尿管结石症中的止痛和止痛剂。