发明公开
- 专利标题: PYRIDINE DERIVATIVES AS NMDA-RECEPTOR SUBTYPE BLOCKERS
- 专利标题(中): 吡啶衍生物AS NMDA受体亚型阻滞剂
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申请号: EP02782972.0申请日: 2002-10-22
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公开(公告)号: EP1443926A1公开(公告)日: 2004-08-11
- 发明人: ALANINE, Alexander , BUETTELMANN, Bernd , HEITZ NEIDHART, Marie-Paule , PINARD, Emmanuel , WYLER, René
- 申请人: F. HOFFMANN-LA ROCHE AG
- 申请人地址: 124 Grenzacherstrasse 4070 Basel CH
- 专利权人: F. HOFFMANN-LA ROCHE AG
- 当前专利权人: F. HOFFMANN-LA ROCHE AG
- 当前专利权人地址: 124 Grenzacherstrasse 4070 Basel CH
- 代理机构: Poppe, Regina
- 优先权: EP01125765 20011029
- 国际公布: WO2003037333 20030508
- 主分类号: A61K31/44
- IPC分类号: A61K31/44 ; A61K31/381 ; C07D213/73 ; C07D213/74 ; C07D409/04
摘要:
The present invention relates to compounds of formulas (IA) or (IB) wherein R1/R2 independently from each other hydrogen, lower alkyl, -(CH2)nNR5R5' or -(CH2)n+1OH; R5 and R5' are independently from each hydrogen, lower alkyl; R3/R4 are independently from each other hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl or hydroxy; Ar is phenyl or thiophenyl; the dotted line is -CH2-CH2-, -CH2-CHR'-, wherein R' is lower alkyl or are two hydrogen atoms, not forming a bridge and; n is 0, 1 or 2; and to pharmaceutically acceptable acid addition salts thereof, with the exception of 6-styryl-pyridin-2-yl-amine. The compounds of the present invention are NMDA (N-methyl-D-aspartate)-receptor subtype blockers and may be used in the treatment of diseases related to this receptor.
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