发明公开
EP1448550A1 TETRAHYDROPYRIDYL-ALKYL-HETEROCYCLES AZOTES AVEC UNE ACTIVITE DU TNF
有权
Azotized四氢ALKYL杂环与TNF活动
- 专利标题: TETRAHYDROPYRIDYL-ALKYL-HETEROCYCLES AZOTES AVEC UNE ACTIVITE DU TNF
- 专利标题(英): Nitrogenous tetrahydropyridyl-alkyl-heterocycles with tnf activity
- 专利标题(中): Azotized四氢ALKYL杂环与TNF活动
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申请号: EP02803433.8申请日: 2002-11-18
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公开(公告)号: EP1448550A1公开(公告)日: 2004-08-25
- 发明人: BARONI, Marco , BOURRIE, Bernard , CASELLAS Pierre , PULEO, Letizia
- 申请人: SANOFI-SYNTHELABO
- 申请人地址: 174, Avenue de France 75013 Paris FR
- 专利权人: SANOFI-SYNTHELABO
- 当前专利权人: SANOFI-SYNTHELABO
- 当前专利权人地址: 174, Avenue de France 75013 Paris FR
- 代理机构: Varady, Peter
- 优先权: FR0114897 20011119
- 国际公布: WO2003044010 20030530
- 主分类号: C07D401/10
- IPC分类号: C07D401/10 ; A61K31/4523 ; A61K31/4545 ; A61P25/00
摘要:
The invention concerns a compound of formula (I), wherein: X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independently represent a hydrogen atom or a C1-C4 alkyl group; R4 represents a hydrogen atom or a C1-C4 alkyl group; n is 0 or 1; A represents a heterocycle selected among pyridine, pyrimidine, pyrazine and pyridazine optionally mono-or di-substituted by a C1-C4 alkyl or C1-C4 alkoxy group; and their N-oxides and their salts or solvates.
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