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14 条记录 (耗时 0.012 秒)

    UTILISATION DE DERIVES DE LA TETRAHYDROPYRIDINE POUR LA PREPARATION DE MEDICAMENTS POUR LE TRAITEMENT DES MALADIES ENTRAINANT UNE DEMYELINISATION
    9.
    发明授权
    UTILISATION DE DERIVES DE LA TETRAHYDROPYRIDINE POUR LA PREPARATION DE MEDICAMENTS POUR LE TRAITEMENT DES MALADIES ENTRAINANT UNE DEMYELINISATION 失效
    TETRAHYDROPYRIDINDERIVATEN的药物来治疗疾病脱髓鞘的生产中使用

    公开(公告)号：EP0979079B1

    公开(公告)日：2004-06-16

    申请号：EP98921552.0

    申请日：1998-04-17

    申请人： SANOFI-SYNTHELABO

    发明人： BOURRIE, Bernard ,  CASELLAS, Pierre ,  MAFFRAND, Jean-Pierre

    IPC分类号： A61K31/44

    CPC分类号： A61K31/444 ,  A61K31/4418

    摘要： The invention concerns the use of tetrahydropyridine derivatives of formula (I) in which: R1 represents a halogen or a CF3, (C1-C4) alkyl or (C1-C4)alkoxy group; Y represents a nitrogen atom or a CH group; Z' and Z" represent each hydrogen or a (C1-C3) alkyl group, or one represents hydrogen and the other a hydroxy group, or both together represent an oxo group; Z represents a phenyl radical; a phenyl radical monosubstituted by a substituent X, X being (a) a (C1-C6)alkyl, (C1-C6)alkoxy (C3-C7)carboxyalkyl, (C1-C4)alkoxycarbonyl(C1-C6)alkyl, (C3-C7)carboxyalkoxy or (C1-C4)-alkoxycarbonyl(C1-C6) alkoxy group; (b) a group selected among a (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C3-C7)cycloalkylmethyl, (C3-C7)cycloalkylamino and cyclohexenyl group, said group capable of being substituted by a halogen, hydroxy, (C1-C4)alkoxy, carboxy, (C1-C4)alkoxycarbonyl, amino, mono- or di-(C1-C4)alkylamino; or (c) a group selected among a phenyl, phenoxy, phenylamino, N-(C1-C3)alkylphenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsulphonyl, phenylsulphinyl or styryl group, said group can be mono- or polysubstituted on the phenyl group by a halogen, CF3, (C1-C4)alkyl, (C1-C4)alkoxy, cyano, amino, mono- or di-(C1-C4)alkylamino, (C1-C4)acylamino, carboxy, (C1-C4)alkoxycarbonyl, aminocarbonyl, mono- or di-(C1-C4)alkylaminocarbonyl, amino(C1-C4)alkyl hydroxy(C1-C4)alkyl or halogeno(C1-C4)alkyl; a phenyl radical disubstituted by a substituent R2, R2 being a halogen or a hydroxy, methyl, ethyl, (C3-C6)alkyl, (C1-C4)alkoxy or trifuoromethyl group and by a substituent X, X being as defined above; a 1-naphthyl or 2-naphthyl radical; a 1-naphthyl or 2-naphthyl radical, substituted in positions 5, 6, 7 and/or 8 by one or two hydroxyl groups, one or two (C1-C4) alkoxy groups, or a 6,7-methylenedioxy group; or Z" is hydrogen and Z and Z' represent, each independently, a phenyl group non-substituted or mono-, di- or trisubstituted; or one of its pharmaceutically acceptable salts or solvates, for preparing pharmaceutical compositions to fight against diseases causing demyelination.

    PHENYL- ET PYRIDYL-PIPERIDINES AVEC UNE ACTIVITY DU TNF
    10.
    发明公开
    PHENYL- ET PYRIDYL-PIPERIDINES AVEC UNE ACTIVITY DU TNF 有权
    苯基和吡啶基 - 哌啶与TNF-有效

    公开(公告)号：EP1383761A1

    公开(公告)日：2004-01-28

    申请号：EP02727675.7

    申请日：2002-04-19

    申请人： SANOFI-SYNTHELABO

    发明人： BARONI, Marco ,  BOURRIE, Bernard ,  CASELLAS, Pierre

    IPC分类号： C07D401/06 ,  A61K31/4725 ,  A61P9/00

    CPC分类号： C07D401/06

    摘要： The invention concerns compounds of formula (I), wherein: X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independently represent a hydrogen atom or a methyl group; n is 0 or 1; A represents a condensed heterocyclic group of formula (W) wherein W completes a ring with 6 atoms, aromatic or saturated containing 1 or 2 nitrogen atoms or a ring with 5 atoms, aromatic or saturated containing a nitrogen, oxygen or sulphur atom optionally substituted; and their N-oxides and their salts or solvates, pharmaceutical compositions and medicines containing same and a method for preparing same.