发明公开
EP1456664A1 USE OF ALPHA-TUBULIN ACETYLATION LEVELS AS A BIOMARKER FOR PROTEIN DEACETYLASE INHIBITORS
审中-公开
ALPHA-微管蛋白乙酰ALS BIOANZEIGER用于蛋白质去乙酰化酶抑制剂的用途
- 专利标题： USE OF ALPHA-TUBULIN ACETYLATION LEVELS AS A BIOMARKER FOR PROTEIN DEACETYLASE INHIBITORS
- 专利标题（中）： ALPHA-微管蛋白乙酰ALS BIOANZEIGER用于蛋白质去乙酰化酶抑制剂的用途
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申请号： EP02795117.7申请日： 2002-12-06
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公开(公告)号： EP1456664A1公开(公告)日： 2004-09-15
- 发明人: ATADJA, Peter, Wisdom , HOVING, Sjouke , TOWBIN, Harry , WALKER, Heather Brownlee , WARTMANN, Markus , YELESWARAPU, Lakshmi
- 申请人： Novartis AG , Novartis Pharma GmbH
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： Novartis AG,Novartis Pharma GmbH
- 当前专利权人： Novartis AG,Novartis Pharma GmbH
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： Grubb, Philip William
- 优先权： US338231P 20011207
- 国际公布： WO2003048774 20030612
- 主分类号： G01N33/574
- IPC分类号： G01N33/574 ; G01N33/50 ; G01N33/68 ; G01N33/53
摘要：
The invention relates to a novel method for evaluating the antiproliferative activity of protein deacetylase inhibiting compounds and microtubule interacting agents, as well as a method for screening for compounds that inhibit cell growth or growth of tumors. The invention additionally provides a method for monitoring the progress of treatment against cellular growth or the growth of tumors.
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