发明公开
EP1461083A1 COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND PROTEIN KINASE (SERINE/THREONINE KINASE) INHIBITORS
有权
基于组合肿瘤的治疗的取代的丙烯酰偏端霉素衍生物和蛋白激酶（丝氨酸/苏氨酸特异性蛋白激酶）抑制剂
- 专利标题： COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND PROTEIN KINASE (SERINE/THREONINE KINASE) INHIBITORS
- 专利标题（中）： 基于组合肿瘤的治疗的取代的丙烯酰偏端霉素衍生物和蛋白激酶（丝氨酸/苏氨酸特异性蛋白激酶）抑制剂
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申请号： EP02787763.8申请日： 2002-12-18
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公开(公告)号： EP1461083A1公开(公告)日： 2004-09-29
- 发明人: GERONI, Maria, Cristina , FOWST, Camilla , COZZI, Paolo
- 申请人： Pharmacia Italia S.p.A.
- 申请人地址： Via Robert Koch 1.2 20152 Milano IT
- 专利权人： Pharmacia Italia S.p.A.
- 当前专利权人： Pharmacia Italia S.p.A.
- 当前专利权人地址： Via Robert Koch 1.2 20152 Milano IT
- 代理机构： Modiano, Micaela Nadia
- 优先权： EP02075052 20020102
- 国际公布： WO2003055522 20030710
- 主分类号： A61K45/06
- IPC分类号： A61K45/06 ; A61K31/40 ; A61K31/415 ; A61P35/00
摘要：
The present invention provides the combined use of acryloyl distamycin derivatives, in particular α-bromo- and α-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and a protein kinase (serine/threonine and tyrosine kinases) inhibitor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.
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