发明公开
EP1465893A1 DERIVES DE 5-(PYRIDIN-3-YL)-1-AZABICYCLO (3.2.1) OCTANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
有权
(5-(吡啶-3-基)-1-氮杂双环(3.2.1)辛烷衍生物,其制备及其用途在治疗“
- 专利标题: DERIVES DE 5-(PYRIDIN-3-YL)-1-AZABICYCLO (3.2.1) OCTANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
- 专利标题(英): Derivatives of 5-(pyridin-3-yl)-1-azabicyclo (3.2.1) octane, the preparation thereof and the application of same in therapeutics
- 专利标题(中): (5-(吡啶-3-基)-1-氮杂双环(3.2.1)辛烷衍生物,其制备及其用途在治疗“
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申请号: EP03712202.5申请日: 2003-01-03
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公开(公告)号: EP1465893A1公开(公告)日: 2004-10-13
- 发明人: GALLI, Frédéric , LECLERC, Odile , LOCHEAD, Alistair , NEDELEC, Alain
- 申请人: SANOFI-SYNTHELABO
- 申请人地址: 174, Avenue de France 75013 Paris FR
- 专利权人: SANOFI-SYNTHELABO
- 当前专利权人: SANOFI-SYNTHELABO
- 当前专利权人地址: 174, Avenue de France 75013 Paris FR
- 代理机构: Ludwig, Jacques
- 优先权: FR0200109 20020107
- 国际公布: WO2003057697 20030717
- 主分类号: C07D471/08
- IPC分类号: C07D471/08 ; A61K31/439 ; A61P25/00
摘要:
The invention relates to compounds having general formula (I), wherein R denotes a halogen atom, a phenyl group which is substituted by one or more groups selected from among halogen atoms and the (Cl-C6) alkyl, (C1-C6) alcoxy, nitro, amino, trifluoromethyl, cyano, hydroxy, acetyl or methylenedioxy groups, a pyridinyl group, a thienyl group, a indolyl group, or a pyrimidinyl group which is optionally substituted by one or more (C1-C6) alcoxy groups. Moreover, among the two carbon-carbon bonds denoted by ----, one is simple and the other can be simple or double. The inventive compounds are nicotinic receptor ligands.
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