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1.发明公开DERIVES DE 4-HETEROARYL-1,4-DIAZABICYCLO 3.2.2]NONANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权4-杂芳基 - 1,4-二氮杂双环3.2.2]壬烷，其制备及其治疗用途
公开(公告)号：EP1254139A1
公开(公告)日：2002-11-06
申请号：EP01907686.8
申请日：2001-01-24
申请人： SANOFI-SYNTHELABO
IPC分类号： C07D487/08 , A61K31/551
CPC分类号： C07D471/08
摘要： The invention concerns compounds of general formula (I) wherein: R1, R2, R3 and R4 represent each a hydrogen or halogen atom or a nitro, amino, trufluoromethyl, cyano, hydroxy, alkyl or alkoxy group; X represents either a nitrogen atom, in which case Z represents a group of formula C-R5 or a nitrogen atom or a group of formula C-R6, in which case Z represents a nitrogen atom, R5 and R6 representing each a hydrogen or halogen atom or a trifluoromethyl, cyano, hydroxy, C1-C6 alkyl or C1-C6 alkoxy group, and R7 represents a hydrogen atom or a C1-C6 alkyl group. Said compounds have therapeutic uses.
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2.发明公开DERIVES DE 1,4-DIAZABICYCLO 3.22]NONANE-PHENYLISOXAZOLE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权恶唑1,4-二氮杂双环[3.2.2]壬烷，生产和治疗剂的用途
公开(公告)号：EP1289986A1
公开(公告)日：2003-03-12
申请号：EP01938361.1
申请日：2001-05-29
申请人： SANOFI-SYNTHELABO
IPC分类号： C07D471/08 , A61K31/55 , A61P25/00
CPC分类号： C07D471/08
摘要： The invention concerns compounds of general formula (I) wherein: R1, R2, R3, R4 and R5 represent each, independently of one another, a hydrogen or halogen atom or a nitro, amino, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, (C1-C6)alkyl, (C1-C6)alkoxy or phenyl group, two of those substituents in adjacent positions capable of representing together a methylenedioxy group, and R6 represents a hydrogen atom or a (C1-C6)alkyl group. The invention also concerns the therapeutic use of said compounds.
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3.发明公开DERIVES DE 5-(PYRIDIN-3-YL)-1-AZABICYCLO (3.2.1) OCTANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权（5-（吡啶-3-基）-1-氮杂双环（3.2.1）辛烷衍生物，其制备及其用途在治疗“
公开(公告)号：EP1465893A1
公开(公告)日：2004-10-13
申请号：EP03712202.5
申请日：2003-01-03
申请人： SANOFI-SYNTHELABO
IPC分类号： C07D471/08 , A61K31/439 , A61P25/00
CPC分类号： C07D471/08
摘要： The invention relates to compounds having general formula (I), wherein R denotes a halogen atom, a phenyl group which is substituted by one or more groups selected from among halogen atoms and the (Cl-C6) alkyl, (C1-C6) alcoxy, nitro, amino, trifluoromethyl, cyano, hydroxy, acetyl or methylenedioxy groups, a pyridinyl group, a thienyl group, a indolyl group, or a pyrimidinyl group which is optionally substituted by one or more (C1-C6) alcoxy groups. Moreover, among the two carbon-carbon bonds denoted by ----, one is simple and the other can be simple or double. The inventive compounds are nicotinic receptor ligands.
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4.发明公开DERIVES DE 4-(OXAZOLOPYRIDIN-2-YL)-1,4-DIAZABICYCLO 3.2.2 NONANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权4-（恶唑-2-基）-1,4-二氮杂双环[3.2.2] -NONANDERIVATE，其制备及其治疗用途
公开(公告)号：EP1451197A1
公开(公告)日：2004-09-01
申请号：EP02803450.2
申请日：2002-11-20
申请人： SANOFI-SYNTHELABO
IPC分类号： C07D519/00 , A61K31/551 , A61P25/28 , A61P25/16
CPC分类号： C07D519/00
摘要： The invention concerns a compound of general formula (I), wherein R2 represents a chlorine atom, a methyl group or a thien-3-yl group. The invention has therapeutic uses.
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5.发明公开DERIVES DE 4-(1,3,4-THIADIAZOL-2-YL)-1,4-DIAZABICYCLO- 3.2.2]NONANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权4-（1,3,4-噻二唑-2-基）-1,4- DIAZABIZYKLO- 3.2.2壬烷衍生物，其制备方法及其治疗用途
公开(公告)号：EP1451189A1
公开(公告)日：2004-09-01
申请号：EP02803453.6
申请日：2002-11-21
申请人： SANOFI-SYNTHELABO
IPC分类号： C07D471/08 , A61K31/55 , A61P25/00
CPC分类号： C07D471/08
摘要： The invention concerns a compound of general formula (I), wherein R represents a phenyl group substituted by one or several halogen atoms, by one or several C1-C6, C1-C6 alkoxy, nitro, amino, trifluoromethoxy, trifluoromethyl, cyano, hydroxy, or methylenedioxy groups, or a pyridinyl group, or a thienyl group optionally substituted by a halogen atom, or a pyrazinyl group. The invention also concerns compounds, nicotinic receptor ligands, useful for treating or preventing disorders related to nicotinic receptor dysfunction, in particular in the central nervous system.
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6.发明公开DERIVES DE 4-(OXADIAZOL-3-YL)-1,4-DIAZABICYCLO 3.2.2]-NONANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权4-（恶二唑-3-基）-1,4-二氮杂双环[3.2.2] -NONANDERIVATE，其制备和治疗用途
公开(公告)号：EP1451188A1
公开(公告)日：2004-09-01
申请号：EP02796853.6
申请日：2002-11-21
申请人： SANOFI-SYNTHELABO
IPC分类号： C07D471/08 , A61K31/55 , A61P25/00
CPC分类号： C07D471/08
摘要： The invention concerns a compound of general formula (I), wherein: R represents a phenyl group substituted by one or several halogen toms, by one or several C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, trifluoromethoxy, trifluoromethyl, cyano, hydroxy, or methylenedioxy groups, or a pyridinyl group, or a thienyl group. The invention also concerns compounds which are nicotinic receptor ligands, and which are useful for treating or preventing disorders related to nicotinic receptor dysfunction, in particular in the central nervous system.
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7.发明授权DERIVES DE 4-(2-PHENYLTHIAZOL-5-YL)-1,4-DIAZABICYCLO- 3.2.2]NONANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权4-（2-苯基 - 噻唑-5-基）1,4-二氮杂双环[3.2.2] NONANEDERIVATE，其制备和治疗用途
公开(公告)号：EP1289987B1
公开(公告)日：2004-05-19
申请号：EP01938362.9
申请日：2001-05-29
申请人： SANOFI-SYNTHELABO
IPC分类号： C07D471/08 , A61K31/55 , A61P25/00
CPC分类号： C07D471/08
摘要： The invention concerns a compound of general formula (I) wherein: R1, R2, R3, R4 and R5 represent each a hydrogen or halogen atom or a nitro, amino, trifluoromethyl, trifluoroalkoxy, cyano, hydroxy, (C1-C6)alkyl or (C1-C6)alkoxy group and R6 represents a (C1-C6)alkyl group. The invention has therapeutic applications.
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8.发明授权DERIVES DE 1,4-DIAZABICYCLO 3.22]NONANE-PHENYLISOXAZOLE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权恶唑1,4-二氮杂双环[3.2.2]壬烷，生产和治疗剂的用途
公开(公告)号：EP1289986B1
公开(公告)日：2004-04-28
申请号：EP01938361.1
申请日：2001-05-29
申请人： SANOFI-SYNTHELABO
IPC分类号： C07D471/08 , A61K31/55 , A61P25/00
CPC分类号： C07D471/08
摘要： The invention concerns compounds of general formula (I) wherein: R1, R2, R3, R4 and R5 represent each, independently of one another, a hydrogen or halogen atom or a nitro, amino, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, (C1-C6)alkyl, (C1-C6)alkoxy or phenyl group, two of those substituents in adjacent positions capable of representing together a methylenedioxy group, and R6 represents a hydrogen atom or a (C1-C6)alkyl group. The invention also concerns the therapeutic use of said compounds.
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9.发明授权DERIVES DE 4-HETEROARYL-1,4-DIAZABICYCLO 3.2.2]NONANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权4-杂芳基 - 1,4-二氮杂双环3.2.2]壬烷，其制备及其治疗用途
公开(公告)号：EP1254139B1
公开(公告)日：2003-08-20
申请号：EP01907686.8
申请日：2001-01-24
申请人： SANOFI-SYNTHELABO
IPC分类号： C07D487/08 , A61K31/551
CPC分类号： C07D471/08
摘要： The invention concerns compounds of general formula (I) wherein: R1, R2, R3 and R4 represent each a hydrogen or halogen atom or a nitro, amino, trufluoromethyl, cyano, hydroxy, alkyl or alkoxy group; X represents either a nitrogen atom, in which case Z represents a group of formula C-R5 or a nitrogen atom or a group of formula C-R6, in which case Z represents a nitrogen atom, R5 and R6 representing each a hydrogen or halogen atom or a trifluoromethyl, cyano, hydroxy, C1-C6 alkyl or C1-C6 alkoxy group, and R7 represents a hydrogen atom or a C1-C6 alkyl group. Said compounds have therapeutic uses.
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10.发明公开DERIVES DE 4-(2-PHENYLTHIAZOL-5-YL)-1,4-DIAZABICYCLO- 3.2.2]NONANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权4-（2-苯基 - 噻唑-5-基）1,4-二氮杂双环[3.2.2] NONANEDERIVATE，其制备和治疗用途
公开(公告)号：EP1289987A1
公开(公告)日：2003-03-12
申请号：EP01938362.9
申请日：2001-05-29
申请人： SANOFI-SYNTHELABO
IPC分类号： C07D471/08 , A61K31/55 , A61P25/00
CPC分类号： C07D471/08
摘要： The invention concerns a compound of general formula (I) wherein: R1, R2, R3, R4 and R5 represent each a hydrogen or halogen atom or a nitro, amino, trifluoromethyl, trifluoroalkoxy, cyano, hydroxy, (C1-C6)alkyl or (C1-C6)alkoxy group and R6 represents a (C1-C6)alkyl group. The invention has therapeutic applications.
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