A protein A binding to the N-methyl-D-aspartic acid NMDA receptor and another protein B interacting with the protein A are provided. Based on the fact that these proteins remarkably promote the signal transfer of the NMDA receptor, controllers inhibitors or promoters for the expression and/or functions of these proteins and a method of controlling the same are provided. Thus, it becomes possible to clarify diseases caused by failures in the NMDA receptor signal transfer or memory regeneration, for example, neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and polyglutamine disease as well as to prevent, ameliorate or treat these diseases.