发明公开
- 专利标题: CONDENSED HETEROCYCLIC COMPOUNDS
- 专利标题(中): 稠合杂环化合物
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申请号: EP03703053.3申请日: 2003-01-27
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公开(公告)号: EP1469854A1公开(公告)日: 2004-10-27
- 发明人: ISHIDA, Junya,c/o Fujisawa Pharmaceut. Co., Ltd. , HATTORI, Kouji,c/o Fujisawa Pharmaceut. Co., Ltd. , KIDO, Yoshiyuki,c/o Fujisawa Pharmaceut. Co., Ltd , YAMAMOTO, Hirofumi,c/o Fujisawa Pharmac. Co. Ltd.
- 申请人: FUJISAWA PHARMACEUTICAL CO., LTD.
- 申请人地址: 4-7, Doshomachi 3-chomeChuo-ku Osaka-shiOsaka 541-8514 JP
- 专利权人: FUJISAWA PHARMACEUTICAL CO., LTD.
- 当前专利权人: FUJISAWA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: 4-7, Doshomachi 3-chomeChuo-ku Osaka-shiOsaka 541-8514 JP
- 代理机构: Prop, Gerrit
- 优先权: AUPS019702 20020129
- 国际公布: WO2003063874 20030807
- 主分类号: A61K31/519
- IPC分类号: A61K31/519 ; A61K31/502 ; A61K31/4725 ; C07D239/88 ; C07D495/04 ; C07D471/04 ; C07D491/04 ; C07D401/06 ; C07D237/32 ; C07D217/24 ; A61K31/517
摘要:
A condensed heterocyclic compound having poly(adenosine 5'-diphospho-ribose)polymerase (PARP) inhibitory activity represented by the formula (I): wherein R1 is hydrogen, halogen, lower alkyl or lower alkoxy, A and two adjacent carbon atoms of the six membered ring to be bonded with A form benzene ring, pyridine ring, etc, -Y1=Y2- is formula (II) wherein L11, L12, L13 and L14 is (1) lower alkylene, (2) lower alkenylene, etc, and R21, R22 , R23 and R24 is (1) cyclic amino group, which is substituted with phenyl optionally substituted with one or more suitable substituent(s), etc. provided that when A and two adjacent carbon atoms of the six membered ring to be bonded with A form benzene ring, then -Y1=Y2- is formula (III) or its prodrug, or their salts.
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