发明公开
EP1474158A2 PREVENTION AND TREATMENT OF OXIDATIVE STRESS DISORDERS BY GLUTATHIONE AND PHASE II DETOXIFICATION ENZYMES
有权
预防和氧化应激疾病治疗链接到细胞内谷胱甘肽镜或相位II解毒酶增加
- 专利标题： PREVENTION AND TREATMENT OF OXIDATIVE STRESS DISORDERS BY GLUTATHIONE AND PHASE II DETOXIFICATION ENZYMES
- 专利标题（中）： 预防和氧化应激疾病治疗链接到细胞内谷胱甘肽镜或相位II解毒酶增加
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申请号： EP02805203.3申请日： 2002-12-18
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公开(公告)号： EP1474158A2公开(公告)日： 2004-11-10
- 发明人: GAO, Xiangqun , DINKOVA-KOSTOVA, Albena, T. , TALALAY, Paul
- 申请人： Brassica Foundation for Chemoprotection Research, Inc.
- 申请人地址： 5512 Boxhill Lane Baltimore, MD 21210 US
- 专利权人： Brassica Foundation for Chemoprotection Research, Inc.
- 当前专利权人： Brassica Foundation for Chemoprotection Research, Inc.
- 当前专利权人地址： 5512 Boxhill Lane Baltimore, MD 21210 US
- 代理机构： Mallalieu, Catherine Louise
- 优先权： US340273P 20011218
- 国际公布： WO2003051313 20030626
- 主分类号： A61K35/78
- IPC分类号： A61K35/78 ; A61K31/70
摘要：
The present invention generally relates to the field of treating oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathione or intracelluar levels of at least one Phase II detoxification enzyme in animal tissue. The present invention also relates to the field of protecting a subject from photooxidation or oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathione or intracellular levels of at least one Phase II detoxification enzyme in the subject. The present invention also relates to a pharmaceutical composition useful for the treatment of oxidative stress disorders.
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