发明公开
- 专利标题： CRYSTALLINE VENLAFAXINE BASE AND NOVEL POLYMORPHS OF VENLAFAXINE HYDROCHLORIDE, PROCESSES FOR PREPARING THEREOF
- 专利标题（中）： 晶体和盐酸文拉法辛新文拉法辛多晶型，用于生产
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申请号： EP02791279.9申请日： 2002-11-20
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公开(公告)号： EP1474379A2公开(公告)日： 2004-11-10
- 发明人: DOLITZKY, Ben-Zion , ARONHIME, Judith , NISNEVICH, Gennady, A. , WIZEL, Shlomit
- 申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD.
- 申请人地址： 5 Basel Street,P.O. Box 3190 49131 Petah Tiqva IL
- 专利权人： TEVA PHARMACEUTICAL INDUSTRIES LTD.
- 当前专利权人： TEVA PHARMACEUTICAL INDUSTRIES LTD.
- 当前专利权人地址： 5 Basel Street,P.O. Box 3190 49131 Petah Tiqva IL
- 代理机构： Gallagher, Kirk James
- 优先权： US428 20011130
- 国际公布： WO2003048082 20030612
- 主分类号： C07C211/00
- IPC分类号： C07C211/00
摘要：
The present invention relates to novel essentially pure venlafaxine and the process of preparation thereof. The present invention also relates to novel solvate forms of venlafaxine hydrochloride and the process of preparation thereof. Furthermore, the present invention provides a novel process for preparing venlafaxine hydrochloride from venlafaxine; the process comprises the steps of: i) preparing a mixture of venlafaxine with acetone; and ii) exposing the mixture in gaseous hydrochloric acid.
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